ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
High Prevalence of Fatty Liver in Bangladeshi Adolescents and Young Adults with Type 2 Diabetes: Key Predictors and Screening Recommendations.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of metabolic dysfunction associated steatotic liver disease in type 2 diabetes mellitus in India: A systematic review and meta-analysis.The Indian journal of medical research · 2026Pooled it
- Early-Onset Type 2 Diabetes in Bangladesh: National Estimates and Risk Correlates.AACE endocrinology and diabetesArticle
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6 authors.
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Abstract
Background: Obesity and insulin resistance are the key pathogenic factors for both metabolic dysfunction-associated steatotic liver disease (MASLD) and type-2 diabetes (T2DM), and their rising prevalence is driving an increase in MASLD cases. Objective: To assess the presence of fatty liver disease by ultrasonography (USG) and to find out its predictors in newly diagnosed young-onset T2DM. Methods: This cross-sectional study enrolled 137 newly diagnosed adolescents and young adult T2DM subjects (aged 10-34 years) by non-probability purposive sampling at a tertiary hospital in Bangladesh. Individuals with a history of alcoholism, pregnancy, infections, endocrinopathies, genetic disorders, or drugs that can cause fatty liver were excluded. Fatty liver was assessed by ultrasonography. C-peptide, anti-GAD65, and anti-IA2 antibodies were measured by chemiluminescent immunoassay, and anti-ZnT8 antibodies by ELISA. Results: Among 137 newly diagnosed adolescents and young adult T2DM patients, 92 (68.1%) had fatty liver on ultrasonography-58 (63%) with grade 1 and 34 (37%) with grade 2. Most were overweight/obese (67.2%), had central obesity (88.3%), and reported low physical activity (68.6%). Fatty liver was significantly associated with older age, higher BMI, WHR, and a positive family history of diabetes. On multivariate analysis, age (OR 1.14, 95% CI 1.04-1.25, p=0.004), positive family history of DM (OR 3.21, 95% CI 1.29-8.22, p=0.012), acanthosis nigricans (OR: 5.05, 95% CI 1.59-16.04, p=0.006), and fasting C-peptide levels (OR 1.46, 95% CI 1.10-1.92; p = 0.007) were significant predictors of fatty liver. Conclusion: Fatty liver is highly prevalent in young-onset T2DM at diagnosis. Age, a positive family history of diabetes, acanthosis nigricans, and elevated fasting C-peptide levels are strong predictors. Routine use of ultrasonography may facilitate early detection and management of liver disease in this population.
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