Evidence map›Paper›PMID 40589353›Full record

Trial reportCNS neuroscience & therapeutics2025

Two Neuroanatomical Subtypes in Fibromyalgia Patients: Distinct Morphological Patterns and Treatment Outcomes.

Shiya Wu, Bin Jing, Yidan Wang, Meijuan Long, Yanting Li, Zihao Li, Juan Jiao

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03890133 (Exploration the Therapeutic Mechanism of Ba-Duan-Jin in the Treatment of Fibromyalgia by Improving Intestinal Microecology), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03890133 nacompletednot on this map

Exploration the Therapeutic Mechanism of Ba-Duan-Jin in the Treatment of Fibromyalgia by Improving Intestinal Microecology

TypeinterventionalSponsorGuang'anmen Hospital of China Academy of Chinese Medical SciencesRan2019 to 2022Enrolled60ConditionsFibromyalgiaArmsBa-Duan-Jin, Pregabalin capsule
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shiya WuRheumatology Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.ORCID 0009-0005-3780-8227
Bin JingSchool of Biomedical Engineering, Capital Medical University, Beijing, China.ORCID 0000-0002-4478-8683
Yidan WangRheumatology Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Meijuan LongRheumatology Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Yanting LiRheumatology Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Zihao LiRheumatology Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Juan JiaoRheumatology Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.ORCID 0000-0002-4370-5137

Funding

Science and Technology Innovation Project of China Academy of Chinese Medical Sciences CI2021A01505
6 · The paper itself

Abstract

objectivesTo better investigate neurobiological heterogeneity in fibromyalgia for its symptom diversity and individual differences.

methodsWe collected structural MRI data and clinical characteristics of Chinese female fibromyalgia patients and healthy controls matched by age and educational level, then invited qualified patients to undergo either Ba-Duan-Jin or pregabalin intervention for 12 weeks randomly. Structural MRI was analyzed by CAT12 software, and the regional volume of gray matter (GMV) was calculated according to the Brainnetome atlas. Fibromyalgia patients were clustered using the HYDRA algorithm to detect disease subtypes.

resultsTwo distinct neuroanatomical subtypes were found among 75 patients. Compared to 93 healthy controls, patients in subtype 1 (n = 38, 50.7%) showed widespread GMV increase, especially in some pain-related brain regions, while no structural changes were observed in subtype 2 (n = 37, 49.3%). At the baseline before treatment, patients in subtype 1 showed a younger age (p = 0.037), longer illness duration (p = 0.042), and a severer psychological stress state evaluated by the Perceived Stress Scale (p = 0.008). After standardized treatment, subtype 1 patients showed less improvement in pain VAS score (p = 0.027) than subtype 2 patients. In addition, GMV of the bilateral dorsal caudate had negative correlations with stress level (Left r = -0.335, p = 0.040; Right r = -0.341, p = 0.036), and GMV of the left rostral temporal thalamus (r = 0.781, p = 0.038) and lateral amygdala (r = 0.761, p = 0.047) were positively related to the improvement of pain severity after treatment in subtype 1 patients.

conclusionsThese two neuroanatomical subtypes in fibromyalgia emphasize different underlying neuropathological processes and need future studies to optimize individualized treatment.

trial registrationClinicalTrials.gov identifier: NCT03890133.

Indexed as

BrainFibromyalgiaAdultAnalgesicsFemaleGray MatterHumansMagnetic Resonance ImagingMiddle AgedPregabalinTreatment OutcomeAnalgesicsPregabalinfibromyalgiagray matter volumeheterogeneitysMRItherapeutic response

Identifiers

PMID40589353
PMCPMC12209714

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.