Evidence map›Paper›PMID 40589014›Full record

ArticlePediatric blood & cancer2025

Caregiver At-Work Productivity Loss at the Time of a Child's Diagnosis With High-Risk Hodgkin Lymphoma: A Report From the Children's Oncology Group AHOD1331 Study.

Daniel J Zheng, Angie Mae Rodday, Sharon M Castellino, Lindsay A Renfro, Debra Lerner, Tara O Henderson, Yue Wu, Kara M Kelly, Rena M Conti, Susan K Parsons

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric blood & cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniel J ZhengDivision of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-2217-088X
Angie Mae RoddayInstitute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA.
Sharon M CastellinoAflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Lindsay A RenfroDivision of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA.
Debra LernerProgram on Health, Work and Productivity, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA.
Tara O HendersonFASCO Department of Pediatrics, Lurie Children's Hospital, Chicago, Illinois, USA.
Yue WuChildren's Oncology Group, Statistics and Data Center, Department of Biostatistics, University of Florida, Gainesville, Florida, USA.
Kara M KellyDepartment of Pediatrics, Roswell Park Comprehensive Cancer Center, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.
Rena M ContiBoston University, Questrom School of Business, Boston, Massachusetts, USA.
Susan K ParsonsDivision of Hematology and Oncology and Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA.

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
COG FOREIGN ACCRUALU10CA098543 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI ADAMSON, PETER C. · 2003 to 2013
$335.5M
COG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8M
Towards a preventive cancer vaccine for children with constitutional mismatch repair deficiencyUG1CA189955 · NCI · PUBLIC HEALTH INSTITUTE · PI BRAD H POLLOCK, Michael E. Roth · 2014 to 2026
$62.5M
Physician Scientist Training in Clinical OncologyK12CA076931 · NCI · UNIVERSITY OF PENNSYLVANIA · PI STEPHEN Patrick HUNGER, LYNN M. SCHUCHTER · 1997 to 2026
$16.5M
American Society of Clinical Oncology Conquer Cancer K12CA076931-22Leukemia and Lymphoma SocietyNational Cancer Institute of the National Institutes of Health K12CA076931-22National Cancer Institute of the National Institutes of Health U10CA098543National Cancer Institute of the National Institutes of Health U10CA180886National Cancer Institute of the National Institutes of Health U10CA180899National Cancer Institute of the National Institutes of Health UG1CA189955NCI NIH HHS K12 CA076931NCI NIH HHS U10 CA098543NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899NCI NIH HHS UG1 CA189955Seagen IncSt Baldrick's Foundation
6 · The paper itself

Abstract

Caregiver work productivity loss is an important spillover in estimating the costs of pediatric cancer diagnosis and treatment. In this prospective multi-institutional study, cross-sectional analysis of 155 caregivers of children with high-risk Hodgkin lymphoma revealed 9% at-work productivity loss in the four weeks leading up to diagnosis including interference in all four domains measured by the Caregiver Work Limitations Questionnaire: time management, physical tasks, mental-interpersonal tasks, and output tasks. The degree of productivity loss experienced by these caregivers at diagnosis is substantial. Longitudinal analysis of caregiver burden throughout treatment is needed to understand the full extent of the economic impact.

Indexed as

CaregiversCost of IllnessEfficiencyHodgkin DiseaseAdolescentAdultChildChild, PreschoolCross-Sectional StudiesFemaleFollow-Up StudiesHumansMalePrognosisProspective StudiesSurveys and Questionnairescaregiver burdenhealth economicspediatric Hodgkin lymphomawork productivity loss

Identifiers

PMID40589014
PMCPMC12395594

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.