ReviewInsect science2026
The JAK-STAT pathway in invertebrates: An emerging battleground for host‒virus warfare.
Review in Insect science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- ThemicroPublication biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The arms race between hosts and viruses for dominance over the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway has been extensively studied in vertebrates but remains poorly explored in invertebrates. Recent studies have revealed that the antiviral Vago/JAK-STAT pathway in invertebrates operates as a parallel mechanism to the vertebrate interferon (IFN)/JAK-STAT pathway, suggesting a highly conserved antiviral mechanism across the animal kingdom. Moreover, invertebrates appear to employ multifaceted strategies to modulate the JAK-STAT pathway to inhibit viral replication or enhance host tolerance, while viruses can counteract by manipulating the JAK-STAT pathway to their advantage. Thus, the competition between hosts and viruses for control of the JAK-STAT pathway also exists in invertebrates, indicating this arms race is also conserved in evolution. This review summarizes the discovery of the Vago/JAK-STAT pathway, its comparison to the IFN/JAK-STAT pathway, and the mechanisms underlying the host-virus tug-of-war over the JAK-STAT pathway in invertebrates. These insights shed light on this highly conserved immune strategy, its implication for host-virus interaction, and its potential application in disease control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.