ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
ARTS is associated with vascular risk factors, MCI, dementia, and stroke.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- MIND diet, cerebrovascular health, and cognition among community-dwelling older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Age at menopause,Research square · 2026Article
- Evaluation of an in vivo biomarker of arteriolosclerosis (ARTS) and its associations with cognition and multimodal ATN(V) biomarkers in a cardiometabolic-risk enriched community cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Evaluation of an in vivo biomarker of arteriolosclerosis (ARTS) and its associations with cognition and multimodal ATN(V) biomarkers in a cardiometabolic-risk enriched community cohort.medRxiv : the preprint server for health sciences · 2025Article
- ARTS as a cardiometabolic biomarker to bridge gaps in dementia diagnostics and therapeutics.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Targeting the cardiometabolic bottleneck to slow polypathology and cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Enhancing uptake of antidiabetic drugs to reduce cardiometabolic risk and dementia burden.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- TPClust: Temporal Profile-Guided Subtyping Using High-Dimensional Omics Data.bioRxiv : the preprint server for biology · 2025Article
- ARTS is associated with vascular risk factors, MCI, dementia, and stroke.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
introductionARTS, an in vivo marker of cerebral arteriolosclerosis, may identify older individuals at risk of mild cognitive impairment (MCI), dementia, and stroke due to cerebral small vessel disease, but deeper characterization in a large, diverse sample is needed.
methodsAssociations between ARTS and incident MCI, dementia, and stroke, and with several common vascular risk factors, were examined in 1226 older adults without dementia and within White (n = 707), Black (n = 400), and Latino (n = 110) subgroups.
resultsHigher ARTS score was associated (all ps < 0.01) with incident MCI (hazard ratio [HR] = 1.29), dementia (HR = 1.33), and stroke (HR = 1.52) and with diastolic/systolic blood pressure, self-reported hypertension, claudication, congestive heart failure, smoking, and glomerular filtration rate in the combined sample. Results varied across racial and ethnic groups. DISCUSSION: ARTS has utility as an in vivo marker of cerebral arteriolosclerosis and risk of MCI, dementia, and stroke. HIGHLIGHTS: ARTS score, an in vivo marker of cerebral arteriolosclerosis, was associated with incident mild cognitive impairment (MCI), dementia, and stroke in a diverse sample. ARTS score was associated with incident dementia in the non-Latino (NL) White and NL Black subgroups separately. ARTS score was associated with incident MCI in the NL Black subgroup. Common vascular risk factors were associated with ARTS score, consistent with ex vivo studies. ARTS has utility as a marker for the risk of MCI, dementia, and stroke.
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