Trial reportAlcohol, clinical & experimental research2025
Acute changes in immune biomarkers under low- and moderate-dose alcohol in light and heavy drinkers: A randomized, placebo-controlled trial.
Trial report in Alcohol, clinical & experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Effects of Acute Low- and Moderate-Dose Alcohol on Chronic Disease-Related Biomarkers in Healthy Light and Heavy Drinkers.Alcohol, clinical & experimental research · 2026Trial
- Embracing the complexity of alcohol's immunomodulatory effects: Commentary on Monnig, Lamb, Clark, and Monti-"Acute changes in immune biomarkers under low and moderate dose alcohol in light and heavy drinkers: A randomized, placebo-controlled trial".Alcohol, clinical & experimental research · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundAlcohol consumption modulates immune function, in part by promoting microbial translocation. This process is thought to trigger an acute-phase immune response, contributing to alcohol-related immune modulation. However, most evidence on these effects arises from preclinical models. Additionally, existing human studies lack a placebo control, rely on a single alcohol dose, or fail to account for individual drinking history.
methodsThis study examined in vivo concentrations of lipopolysaccharide (LPS, a marker of microbial translocation), acute-phase proteins, cytokines, and chemokines under low-dose alcohol, moderate-dose alcohol, and placebo using a within-subjects design in light and heavy drinkers. Participants (N = 32) were light drinkers (n = 15) and nontreatment-seeking heavy drinkers (n = 17). Groups did not differ on demographics. Participants received each dose condition in randomized order. Blood samples were collected at baseline and at hourly intervals for 4 h. Plasma concentrations of LPS, acute-phase proteins (LPS binding protein [LBP], soluble cluster of differentiation 14 [sCD14], and soluble cluster of differentiation 163 [sCD163]), and cytokines/chemokines (interleukin 6 [IL-6], interleukin 8 [IL-8], interleukin 10 [IL-10], monocyte chemoattractant protein [MCP-1], and tumor necrosis factor alpha [TNF-α]) were quantified using immunoassays. Linear mixed models tested effects of dose condition, drinker group, time, and the three-way interaction. Further analyses tested associations of LPS, LBP, sCD14, and sCD163 with cytokines/chemokines.
resultsThe three-way interaction of dose by group by time was significant for IL-6 (p = 0.042), IL-8 (p = 0.039), MCP-1 (p = 0.001), and TNF-α (p = 0.001). LPS was associated with concentrations of interleukins. Levels of sCD163 were 43% higher in heavy drinkers overall. Heavy drinkers exhibited apparent conditioned peripheral immune suppression, wherein the expectation of alcohol elicited selective immunosuppressive responses.
conclusionsThis study offers novel in vivo evidence that alcohol-induced changes in immune function are dependent on both acute dose and chronic drinking behavior.
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