Evidence map›Paper›PMID 40588684›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Generalized cortical encephalitis in autoimmune GFAP astrocytopathy.

Yu Guo, Hongjun Hao, Yunchuang Sun

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yu GuoDepartment of Neurology, Peking University First Hospital, Xicheng District, Beijing, China.
Hongjun HaoDepartment of Neurology, Peking University First Hospital, Xicheng District, Beijing, China.
Yunchuang SunDepartment of Neurology, Peking University First Hospital, Xicheng District, Beijing, China. sychuang0805@163.com.ORCID http://orcid.org/0000-0001-6069-695X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a rare case of autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) presenting with generalized cortical encephalitis. A 51-year-old woman developed subacute cognitive decline and seizure. Brain MRI revealed diffuse cortical T2-FLAIR hyperintensities, sulcal effacement, cerebral edema, and diffuse leptomeningeal enhancement. Anti-GFAP antibody was detected in both serum and cerebrospinal fluid. The patient responded well to immunotherapy, with significant clinical and radiological improvement. This case further expands the phenotypic spectrum of GFAP-A and suggests potential heterogeneity in its underlying pathogenesis.

Indexed as

AstrocytesAutoimmune Diseases of the Nervous SystemCerebral CortexEncephalitisGlial Fibrillary Acidic ProteinAutoantibodiesFemaleHumansMagnetic Resonance ImagingMiddle AgedAutoantibodiesGFAP protein, humanGlial Fibrillary Acidic ProteinAutoimmune glial fibrillary acidic protein astrocytopathyCognitive impairmentMagnetic resonance imagingMeningoencephalitis

Identifiers

PMID40588684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.