ArticlePhysiological reports2025
Altered cardiac-coronary coupling relates to abnormal fractional flow reserve without flow limitation after percutaneous coronary interventions.
Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Coronary artery disease in patients undergoing transcatheter aortic valve replacement: Current evidence and future directions.American heart journal plus : cardiology research and practice · 2026Review
- Altered cardiac-coronary coupling relates to abnormal fractional flow reserve without flow limitation after percutaneous coronary interventions.Physiological reports · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
A significant proportion of stenoses have an abnormal fractional flow reserve (FFR) after angiographically successful percutaneous coronary intervention (PCI), which is traditionally attributed to differences in coronary flow velocity reserve (CFVR) or hyperemic microvascular resistance (hMR). This study investigated the mechanisms underlying residual low FFR despite good angiographic results and normalized hyperemic stenosis resistance (hSR) using wave-intensity analysis (WIA), which evaluates phasic characteristics of cardiac-coronary coupling. Sixty-three vessels from patients who underwent PCI for stable intermediate stenoses were included. Peri-PCI characteristics of conventional and WIA parameters were assessed. Ten (16%) vessels exhibited residual low FFR (≤0.8) despite normalized hSR (<0.8), without significant differences in hyperemic flow (velocity) (hAPV), CFVR, or hMR compared with concordant normal FFR-hSR group (p > 0.05). WIA revealed a significantly slower (peak-time of backward expansion wave, tBEW
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