ArticleNature aging2025
Nonuniversality of inflammaging across human populations.
Article in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Circulating Myokine Responses to Acute Endurance Exercise and Their Role in Immunoregulation: A Systematic Review and Meta-Analysis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Pooled it
- Frailty prediction models in older adults with stroke in China: A systematic review and meta-analysis.International journal of nursing studies advances · 2026Review
- Gero-Immunology: The critical role of aging when defining immune phenotypes.Current opinion in biomedical engineering · 2026Article
- A novel soil-derived Mycolicibacterium decreases anxiety-like defensive behavioral responses in association with decreases in biomarkers of neuroinflammation and hippocampal microglial priming in adult male rats.Brain, behavior, and immunity · 2026Article
- Evolutionary genetics of ageing.Nature reviews. Genetics · 2026Review
- The immunology behind inflammaging-causes, sources, and mechanisms.The Journal of allergy and clinical immunology · 2026Review
- NADAging cell · 2026Article
- Divergent biological consequences of APOE isoforms across industrialized and non-industrial environments.PLoS genetics · 2026Article
- The long-lived immune system of centenarians.Nature reviews. Immunology · 2026Review
- The role of toll-like receptors in tributyltin-, dibutyltin-, and pentachlorophenol-induced stimulation of tumor necrosis factor-alpha (TNFα) production in human immune cells.Archives of toxicology · 2026Article
- Review
- CCL2: A Pro-Inflammatory Driver and Candidate Diagnostic Biomarker in Colorectal Cancer Patients.International journal of molecular sciences · 2026Article
- Peripheral transcriptomic aging acceleration in major depressive disorder: the mediating role of insular cortex alterations.Psychological medicine · 2026Article
- Immune aging biomarkers for clinical trials.Nature medicine · 2026Review
- Inflammaging mediates testosterone declines in men while maintaining high testosterone increases mortality risk.bioRxiv : the preprint server for biology · 2026Article
- Microglia in systemic neuroimmune communication: functions beyond phagocytosis.Trends in immunology · 2026Review
- Compartment-specific soluble immune profiles associated with preterm birth, perinatal death, and low birthweight in pregnant individuals living with HIV.bioRxiv : the preprint server for biology · 2026Article
- Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria-Mediated Intestinal Aging and Barrier Dysfunction.Aging cell · 2026Article
- The naked mole-rat microbiome is associated with healthy aging and social structure.Cell reports · 2026Article
- Concurrent associations between objective markers and subjective markers of aging with indicators of successful aging: An integrative approach.European journal of ageing · 2026Article
Corrections and comments
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Authors and funding
29 authors.
Funding
Abstract
Inflammaging, an age-associated increase in chronic inflammation, is considered a hallmark of aging. However, there is no consensus approach to measuring inflammaging based on circulating cytokines. Here we assessed whether an inflammaging axis detected in the Italian InCHIANTI dataset comprising 19 cytokines could be generalized to a different industrialized population (Singapore Longitudinal Aging Study) or to two indigenous, nonindustrialized populations: the Tsimane from the Bolivian Amazon and the Orang Asli from Peninsular Malaysia. We assessed cytokine axis structure similarity and whether the inflammaging axis replicating the InCHIANTI result increased with age or was associated with health outcomes. The Singapore Longitudinal Aging Study was similar to InCHIANTI except for IL-6 and IL-1RA. The Tsimane and Orang Asli showed markedly different axis structures with little to no association with age and no association with age-related diseases. Inflammaging, as measured in this manner in these cohorts, thus appears to be largely a byproduct of industrialized lifestyles, with major variation across environments and populations.
Indexed as
Identifiers
40588649What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.