Evidence map›Paper›PMID 40588613›Full record

ArticleJournal of cardiovascular translational research2025

Intracoronary Stenting and Restenosis - Randomized Trial of Drug-Eluting Stent Implantation or Drug-Coated Balloon Angioplasty According to Neointima Morphology in Drug-Eluting Stent REstenosis 5: Rationale and Design of the ISAR-DESIRE 5 Trial.

Fiorenzo Simonetti, Felix Voll, Fernando Alfonso, Christian Gräßer, Marion Janisch, Michael Joner, Thorsten Kessler, Constantin Kuna, David Manuel Leistner, Tobias Lenz and 9 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05544864 (Intracoronary Stenting and Restenosis - Randomized Trial of Drug-eluting Stent Implantation or Drug-coated Balloon Angioplasty According to Neointima Morphology in Drug-eluting Stent Restenosis 5), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05544864 narecruitingnot on this map

Intracoronary Stenting and Restenosis - Randomized Trial of Drug-eluting Stent Implantation or Drug-coated Balloon Angioplasty According to Neointima Morphology in Drug-eluting Stent Restenosis 5

TypeinterventionalSponsorDeutsches Herzzentrum MuenchenRan2022 to 2026Enrolled376ConditionsCoronary Artery Disease, Restenoses, CoronaryArmsDrug eluting stent (DES), Drug coated ballloon (DCB)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Fiorenzo SimonettiKlinik Für Herz- Und Kreislauferkrankungen, TUM Klinikum Deutsches Herzzentrum, Technische Universität München, Munich, Germany.
Felix VollKlinik Für Herz- Und Kreislauferkrankungen, TUM Klinikum Deutsches Herzzentrum, Technische Universität München, Munich, Germany.
Fernando AlfonsoDepartment of Cardiology, Hospital Universitario de La Princesa, IIS-IP, CIVER-CV, Madrid, Spain.
Christian GräßerKlinik Für Herz- Und Kreislauferkrankungen, TUM Klinikum Deutsches Herzzentrum, Technische Universität München, Munich, Germany.
Marion JanischKlinik Für Herz- Und Kreislauferkrankungen, TUM Klinikum Deutsches Herzzentrum, Technische Universität München, Munich, Germany.
Michael JonerKlinik Für Herz- Und Kreislauferkrankungen, TUM Klinikum Deutsches Herzzentrum, Technische Universität München, Munich, Germany.
Thorsten KesslerKlinik Für Herz- Und Kreislauferkrankungen, TUM Klinikum Deutsches Herzzentrum, Technische Universität München, Munich, Germany.
Constantin KunaKlinik Für Herz- Und Kreislauferkrankungen, TUM Klinikum Deutsches Herzzentrum, Technische Universität München, Munich, Germany.
David Manuel LeistnerUniversitäres Herz- Und Gefäßzentrum, Universitätsklinikum Frankfurt, Frankfurt, Germany.
Tobias LenzKlinik Für Herz- Und Kreislauferkrankungen, TUM Klinikum Deutsches Herzzentrum, Technische Universität München, Munich, Germany.
Antonia PreschKlinik Für Herz- Und Kreislauferkrankungen, TUM Klinikum Deutsches Herzzentrum, Technische Universität München, Munich, Germany.
Tobias RheudeKlinik Für Herz- Und Kreislauferkrankungen, TUM Klinikum Deutsches Herzzentrum, Technische Universität München, Munich, Germany.
Hendrik SagerKlinik Für Herz- Und Kreislauferkrankungen, TUM Klinikum Deutsches Herzzentrum, Technische Universität München, Munich, Germany.
Heribert SchunkertKlinik Für Herz- Und Kreislauferkrankungen, TUM Klinikum Deutsches Herzzentrum, Technische Universität München, Munich, Germany.
Fabian StarneckerKlinik Für Herz- Und Kreislauferkrankungen, TUM Klinikum Deutsches Herzzentrum, Technische Universität München, Munich, Germany.
Jens WiebeDeutsches Zentrum Für Herz-Kreislauf-Forschung, Munich, Germany.
Adnan KastratiKlinik Für Herz- Und Kreislauferkrankungen, TUM Klinikum Deutsches Herzzentrum, Technische Universität München, Munich, Germany.
Salvatore CasseseKlinik Für Herz- Und Kreislauferkrankungen, TUM Klinikum Deutsches Herzzentrum, Technische Universität München, Munich, Germany. cassese@dhm.mhn.de.ORCID 0000-0002-8668-4313
Erion XhepaKlinik Für Herz- Und Kreislauferkrankungen, TUM Klinikum Deutsches Herzzentrum, Technische Universität München, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In-stent restenosis (ISR) is the leading cause of revascularization failure, occurring in up to 10% of patients within 10 years after drug-eluting stent (DES) implantation, and is associated with increased mortality and rehospitalization. Guideline-writing authorities recommend DES over drug-coated balloons (DCB) for ISR treatment. However, this indication is mainly based on trials that did not incorporate intravascular imaging. Recent findings suggest that optical coherence tomography (OCT) patterns in ISR may influence treatment outcomes. The ISAR-DESIRE 5 trial is a randomized study to evaluate whether OCT-defined ISR tissue morphology affects treatment with DES versus DCB. 376 patients with ISR will be stratified by OCT pattern (homogeneous vs. non-homogeneous) and randomized 1:1 to DES or DCB. The trial is powered to detect an interaction between OCT pattern and treatment modality on the 24-month incidence of major adverse cardiac events and represents a step toward establishing a more individualized approach to ISR management.Trial registration (ClinicalTrials.gov): NCT05544864.

Indexed as

Angioplasty, Balloon, CoronaryCoated Materials, BiocompatibleCoronary Artery DiseaseCoronary RestenosisCoronary VesselsDrug-Eluting StentsNeointimaPercutaneous Coronary InterventionTomography, Optical CoherenceCardiac CathetersHumansMulticenter Studies as TopicPredictive Value of TestsProsthesis DesignRandomized Controlled Trials as TopicRisk FactorsCoated Materials, BiocompatibleDrug-coated balloonDrug-eluting stentIn-stent restenosisOptical coherence tomographyPercutaneous coronary intervention

Identifiers

PMID40588613
PMCPMC12630265

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.