Evidence map›Paper›PMID 40588605›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Daily assessment of oral mucositis during volumetric modulated arc therapy planning technique for head and neck cancer: risk factors and impact on nutritional status.

Marcella Ferreira Gobbi, Fernanda de Paula Eduardo, Letícia Mello Bezinelli, Lívia Goron Bergamin, Danielle Lima Correa de Carvalho, Carolina Moreno Dos Santos, Eduardo Weltman, Luciana Corrêa

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Marcella Ferreira GobbiHospital Israelita Albert Einstein, São Paulo, Brazil.
Fernanda de Paula EduardoHospital Israelita Albert Einstein, São Paulo, Brazil.
Letícia Mello BezinelliHospital Israelita Albert Einstein, São Paulo, Brazil.
Lívia Goron BergaminHospital Israelita Albert Einstein, São Paulo, Brazil.
Danielle Lima Correa de CarvalhoHospital Israelita Albert Einstein, São Paulo, Brazil.
Carolina Moreno Dos SantosHospital Israelita Albert Einstein, São Paulo, Brazil.
Eduardo WeltmanHospital Israelita Albert Einstein, São Paulo, Brazil.
Luciana CorrêaSchool of Dentistry, University of São Paulo, São Paulo, Brazil. lcorrea@usp.br.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) 001
6 · The paper itself

Abstract

purposeTo examine the occurrence, timing, and radiation dose associated with oral mucositis (OM) and body weight change in patients who underwent head and neck radiotherapy (RT) using the Volumetric Modulated Arc Therapy (VMAT) technique. It was also investigated whether these side effects affected nutritional status.

methodsData regarding age, gender, tumor type, radiation doses, OM, weight loss, diet, and prescriptions for nasoenteral tubes and gastrostomy were collected retrospectively from 84 medical records of a single head and neck VMAT service.

resultsSevere OM was observed in 61.8% of patients, occurring at a median cumulative dose of 37.7 Gy. Severe OM was significantly associated with radiation doses to the oral cavity and with concurrent chemotherapy, the latter being identified as a predictive factor. A median body weight loss of 6.1 kg was found in the majority of patients. Severe OM was linked with weight loss and the need for artificial nutrition.

conclusionThe frequency of OM in the oral cavity was high in patients treated with VMAT, significantly impacting nutritional status. Radiation dose to the oral mucosa and concurrent chemotherapy were associated with severe OM.

Indexed as

Head and Neck NeoplasmsNutritional StatusRadiotherapy, Intensity-ModulatedStomatitisAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedRadiotherapy DosageRetrospective StudiesRisk FactorsWeight LossHead-and-neck cancerOral mucositisOral toxicityVolumetric modulated arc therapy

Identifiers

PMID40588605

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.