Evidence map›Paper›PMID 40588587›Full record

ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2025

Fine-mapping of sm6.1, a novel locus conferring resistance to gray leaf spot from Solanum habrochaites accession LA1777.

Xiaoxiao Lu, Xin Li, Chunyang Pan, Junling Hu, Feng Pan, Lianfeng Shi, Chen Zhang, Ranran Zhang, Zejun Huang, Can Zhu and 5 more

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Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Xiaoxiao Lu *State Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Xin Li *State Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Chunyang PanState Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Junling HuState Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Feng PanState Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Lianfeng ShiState Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Chen ZhangState Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Ranran ZhangState Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Zejun HuangState Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Can ZhuState Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Yanmei GuoState Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Xiaoxuan WangState Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Yongchen DuState Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Lei LiuState Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081, China. liulei02@caas.cn.
Junming LiState Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081, China. lijunming@caas.cn.ORCID http://orcid.org/0000-0002-6006-9427

Funding

Innovative Research Group Project of the National Natural Science Foundation of China 32272732Key Research and Development Project of Henan Province 221111110800Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences CAAS-ASTIP-IVFCAAS
6 · The paper itself

Abstract

key messageThe single recessive locus, sm6.1, conferring high resistance to gray leaf spot and was fine-mapped to a 78.4 kb region on chromosome 6 of tomato through a genetic mapping strategy. Gray leaf spot (GLS), caused by the necrotrophic fungal pathogen of the genus Stemphylium, is one of the most prevalent and destructive foliar diseases affecting tomato production worldwide. In this study, we identified a novel resistance locus, designated sm6.1, derived from the wild tomato species Solanum habrochaites accession LA1777, which confers high resistance to Stemphylium solani. Genetic analysis revealed that resistance conferred by the sm6.1 locus follows a recessive inheritance pattern. Through genetic mapping strategy, we fine-mapped the sm6.1 locus to a 78.4 kb region on chromosome 6, containing nine annotated genes based on the tomato reference genome Heinz 1706 (SL4.0, ITAG4.0). By integrating synteny analysis, sequence variation screening, and expression analysis, we identified Solyc06g053340 and Solyc06g053350 as the critical candidate genes underlying sm6.1. To facilitate marker-assisted breeding, we developed InDel markers that are tightly linked to the sm6.1 locus. The identification and fine-mapping of sm6.1 not only provide a novel genetic resource for breeding GLS-resistant tomato cultivars but also establish a foundation for elucidating the molecular mechanisms underlying GLS resistance in tomato.

Indexed as

Disease ResistancePlant DiseasesSolanumSolanum lycopersicumAscomycotaChromosome MappingChromosomes, PlantGenes, PlantGenetic LinkageGenetic MarkersPhenotypePlant LeavesQuantitative Trait LociSyntenyGenetic Markers

Identifiers

PMID40588587

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.