Evidence map›Paper›PMID 40588415›Full record

ArticleThorax2025

Maternal prenatal carotenoids and child lung function: exploration of modifying factors.

Xueying Zhang, Terryl J Hartman, Margaret Adgent, Paul Moore, Tebeb Gebretsadik, Marshae Nickelberry, Kaja Z LeWinn, Qi Zhao, Kecia N Carroll, Rosalind J Wright

Abstract read
In one paragraph

Article in Thorax, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xueying ZhangDepartment of Environment Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0003-0806-3324
Terryl J HartmanDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.ORCID 0000-0001-5942-3161
Margaret AdgentDepartment of Health Policy, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-5951-5514
Paul MooreDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-5123-207X
Tebeb GebretsadikDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-4548-3010
Marshae NickelberryHarvard T.H. Chan School of Public Health, Harvard University, Cambridge, Massachusetts, USA.ORCID 0000-0001-5756-493X
Kaja Z LeWinnDepartment of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-8245-7279
Qi ZhaoDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.ORCID 0000-0002-5079-1803
Kecia N CarrollDepartment of Environment Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA kecia.carroll@mssm.edu.ORCID 0000-0002-6646-1374
Rosalind J WrightDepartment of Environment Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-4262-2807

Funding

Mount Sinai ECHO site for Perinatal Environment and Development StudiesUH3OD023337 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KECIA Nicole CARROLL, Robert O Wright · 2018 to 2026
$54.1M
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Maria Jose Rosa · 2014 to 2026
$21.3M
Mount Sinai ECHO site for Perinatal Environment and Development StudiesUG3OD023337 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CARROLL, KECIA NICOLE, WRIGHT, ROBERT O · 2016 to 2024
$20.6M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUG3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2016 to 2017
$5.1M
Maternal Traumatic Stress, Oxidative Stress, Antioxidant Exposures, and Child Asthma and Lung FunctionR01HL132338 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CARROLL, KECIA NICOLE, WRIGHT, ROSALIND J · 2017 to 2021
$3.8M
Pregnancy Folate Status & Early Childhood Respiratory & Atopic Disease OutcomesR01HL109977 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CARROLL, KECIA NICOLE · 2011 to 2015
$3.4M
Retaining the diverse CANDLE cohort to advance ECHO Cohort solution-oriented research and identify early-life modifiable risk factors for obesity and mental health problems in childrenUG3OD035519 · OD · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI BUSH, NICOLE RENEE, LEWINN, KAJA ZABRINA · 2023 to 2024
$2.9M
Retaining the CANDLE cohort to advance ECHO Cohort solution-oriented research and identify early-life modifiable risk factors for obesity and mental health problems in childrenUH3OD035519 · OD · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Nicole Renee Bush, Kaja Zabrina LeWinn · 2025 to 2026
$2.2M
Midcareer Investigator Award in Patient-Oriented Research in Pediatric AsthmaK24HL150312 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KECIA Nicole CARROLL · 2020 to 2026
$805k
NCATS NIH HHS UL1 TR004419NHLBI NIH HHS K24 HL150312NHLBI NIH HHS R01 HL109977NHLBI NIH HHS R01 HL132338NIEHS NIH HHS P30 ES023515NIH HHS UG3 OD023271NIH HHS UG3 OD023337NIH HHS UG3 OD035519NIH HHS UH3 OD023271NIH HHS UH3 OD023337NIH HHS UH3 OD035519
6 · The paper itself

Abstract

backgroundWhile childhood airway outcomes have been associated with prenatal nutrition, few studies examined carotenoids, a group of nutrients with antioxidant properties, as potential modifiers.

objectivesIn n=677 mother-child dyads enrolled in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood cohort, we examined associations between prenatal carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lycopene and zeaxanthin) and child lung function at ages 8-9 years. Maternal-child factors that may modify associations were also assessed.

methodsSecond-trimester plasma carotenoid concentrations were assayed and corrected for cholesterol. Outcomes included forced expiratory volume in one second (FEV

resultsWe did not detect statistically significant associations between individual carotenoid concentrations and child lung function in main effect models. Modifying effects of prenatal smoking were observed between all five carotenoids and FEV

conclusionA protective association between higher prenatal carotenoid concentrations and FEV

Indexed as

CarotenoidsLungPrenatal Exposure Delayed EffectsAdultAsthmaChildFemaleForced Expiratory VolumeHumansMalePregnancyPregnancy Trimester, SecondSmokingVital CapacityCarotenoidsChildClinical EpidemiologyDietary IntakeRespiratory MeasurementSmoking

Identifiers

PMID40588415
PMCPMC12373145

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.