ArticleJournal of neurophysiology2025
Experience-induced NPAS4 reduces dendritic inhibition from CCK+ inhibitory neurons and enhances plasticity.
Article in Journal of neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- NPAS4 refines spatial and temporal firing in CA1 pyramidal neurons.bioRxiv : the preprint server for biology · 2026Article
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4 authors.
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Abstract
Flexibility of neurological systems stems from a host of biological responses to changing experience. When a mouse explores an enriched environment, neurons throughout the brain express the inducible transcription factor NPAS4. In CA1 of the hippocampus, pyramidal neurons that express NPAS4 receive more perisomatic inhibition from cholecystokinin (CCK+) inhibitory neurons and less dendritic inhibition from a previously unidentified inhibitory neuron population. Here, we show that this reduction in dendritic inhibition is specific to synapses made by CCK+ inhibitory neurons and that these NPAS4-dependent changes result in facilitation of theta-burst synaptic plasticity. Thus, NPAS4 expression reorganizes inhibition from a genetically defined population of inhibitory neurons, changing learning rules in response to an animal's interactions with its environment.
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