Evidence map›Paper›PMID 40588325›Full record

ReviewCold Spring Harbor perspectives in biology2025

Engineered In Vitro Platforms for Mechanochemical Control of Cell Migration.

Bishwa Ranjan Si, Qinling Yuan, Sanjiban Nath, Bhawana Agarwal, Alice Amitrano, Debanik Choudhury, Konstantinos Konstantopoulos

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bishwa Ranjan SiDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA.
Qinling YuanDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA.
Sanjiban NathDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA.
Bhawana AgarwalDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA.
Alice AmitranoDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA.
Debanik ChoudhuryDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA.
Konstantinos KonstantopoulosDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA konstant@jhu.edu.

Funding

The interplay of ion transporters and cytoskeleton in breast cancer migration and metastasisR01CA254193 · NCI · JOHNS HOPKINS UNIVERSITY · PI KONSTANTOPOULOS, KONSTANTINOS, MARTIN, STUART S · 2021 to 2025
$2.7M
Viscotaxis: Novel cell migration mechanisms regulated by microenvironmental viscosityR01CA257647 · NCI · JOHNS HOPKINS UNIVERSITY · PI KONSTANTOPOULOS, KONSTANTINOS · 2021 to 2025
$2.3M
The interplay of extracellular fluid viscosity, stiffness and confinement in regulating cell responsesR35GM156305 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Konstantinos Konstantopoulos · 2025 to 2026
$959k
NCI NIH HHS R01 CA254193NCI NIH HHS R01 CA257647NIGMS NIH HHS R35 GM156305
6 · The paper itself

Abstract

Cell migration in confined environments follows distinct mechanisms compared to conventional 2D migration. By using in vitro models and incorporating extracellular cues from the tissue microenvironment, we can gain deeper insights into the complexities of cell migration. In this work, we explore various engineered in vitro models to study cell migration. We delve into biophysical tools, such as traction force microscopy, to understand how cells generate forces in response to their surroundings. We highlight the use of novel optogenetic tools for precise, spatiotemporal control of protein expression at the cellular level. Lastly, we examine emerging therapeutic strategies designed to target abnormal cell migration.

Indexed as

Cell MovementAnimalsBiomechanical PhenomenaHumansOptogenetics

Identifiers

PMID40588325
PMCPMC12487712

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.