ReviewGastroenterology2025
Circadian Rhythms in Gastroenterology: The Biological Clock's Impact on Gut Health.
Review in Gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Chronotherapy in Inflammatory Bowel Disease: Biological Rationale, Human Evidence, and a Clinical Implementation Framework.Digestive diseases and sciences · 2026Review
- Evaluation of pan-alimentary MRI examinations: intrasubject variability and examination duration.Abdominal radiology (New York) · 2026Article
- Screening Biomarkers Related to Circadian Rhythm of Gastric Cancer Through Bioinformatics.Applied biochemistry and biotechnology · 2026Article
- Higher Daytime Light Exposure Predicts Lower Risk of Gastrointestinal Cancer Incidence and Mortality.International journal of cancer · 2026Article
- Article
- Dietary Regulation of Intestinal Stem Cell Function: Nutrient-Sensing, Microbiota-Mediated, and Regenerative Mechanisms from a Dietetic Perspective.Biomedicines · 2026Review
- Chrono-atlas of cell-type specific daily gene expression rhythms in the regenerating colon.Nature communications · 2026Article
- Joint associations of sleep quality and depressive symptoms with incident digestive disease in a nationally representative Chinese cohort.Scientific reports · 2026Article
- The Gastro-Circadian Metabolic Axis: A Comprehensive Framework for Chronotherapy in Gastroenterology.Cureus · 2026Review
- Chrononutrition-based dietary strategies for effective weight loss.European journal of clinical nutrition · 2026Article
- CLOCK is an Epigenetic Integrator of Circadian Rhythm and T Cell Immunity.Research square · 2026Article
- Article
- From mouth to muscle: mechanistic and interventional perspectives on the tongue-coating microbiome in sarcopenia.Journal of translational medicine · 2026Review
- Timing matters: circadian rhythm disruption in alcohol-associated peripheral organ pathophysiology.Function (Oxford, England) · 2026Review
- Circadian regulation of osteoclast lysosomal-resorption machinery: implications for osteoporosis therapy.Frontiers in cell and developmental biology · 2026Review
- Circadian rhythms of gut microbiota modulate nocturnal hyperglycemia in type 2 diabetes: a comprehensive review on mechanisms and chrono-targeted interventions.Frontiers in microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Chronic gastrointestinal (GI) diseases, including functional, inflammatory, and neoplastic conditions, are increasing globally, partly due to modern lifestyles. The circadian rhythm, regulated by the central clock in the hypothalamus and synchronized with peripheral clocks in the GI organs, orchestrates GI functions in response to environmental cycles. This clock is influenced by cues such as light, sleep, and eating times. The circadian machinery prepares the host to cope with environmental conditions to adjust cellular and organ function accordingly. Modern behaviors-like night-time light exposure, travel across time zones, shift work, mistimed eating, and social jet lag-disrupt the circadian clock, affecting GI processes such as digestion, absorption, motility, intestinal barrier function, immune function, and the microbiome, promoting not only GI pathology, but also systemic inflammatory and metabolic disorders. This review summarizes the circadian rhythm's role in normal GI function, examines the consequences of circadian disruption in the GI tract, and discusses circadian-based therapeutic interventions. These interventions aim to realign the circadian clock with external cues or optimize medication timing according to biological rhythms. Understanding the role of the circadian clock in GI conditions can provide preventive and therapeutic opportunities to reduce the burden of GI diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.