Evidence map›Paper›PMID 40587946›Full record

ArticleCardiology2026

A Novel Hydrodynamic Approach for the Evaluation of Microvascular Resistance during Provocative Spasm Testing.

Navid Freidoonimehr, Olivia Girolamo, Tam Atkins, Bo Yang, Rosanna Tavella, Christopher Zeitz, Maziar Arjomandi, John F Beltrame

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Navid FreidoonimehrAdvanced Cardiorespiratory Engineering Laboratory, School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, Queensland, Australia.
Olivia GirolamoAdelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia.
Tam AtkinsSchool of Electrical and Mechanical Engineering, University of Adelaide, Adelaide, South Australia, Australia.
Bo YangSchool of Electrical and Mechanical Engineering, University of Adelaide, Adelaide, South Australia, Australia.
Rosanna TavellaAdelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia.
Christopher ZeitzAdelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia.
Maziar ArjomandiSchool of Electrical and Mechanical Engineering, University of Adelaide, Adelaide, South Australia, Australia.
John F BeltrameAdelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia, john.beltrame@adelaide.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

<p>Introduction: Intracoronary acetylcholine provocative testing is the gold standard method for the assessment of epicardial and/or microvascular spasm, with the latter diagnosed when there are acetylcholine (ACh)-induced chest pain and ischaemic electrocardiogram changes in the absence of epicardial spasm. While epicardial spasm can be visualised, microvascular spasm cannot and remains a presumed diagnosis. Methods: This article describes a hydrodynamic model developed to calculate the epicardial and microvascular resistances for both pre- and post-ACh administration. The model is based on the concept of two resistances (epicardial and microvascular) located in a series arrangement. The epicardial resistance is obtained as a hydraulic resistance, accounting for the friction resistance between the coronary blood flow and the arterial walls. The microvascular resistance is calculated by subtracting the epicardial resistance from the ratio of the pressure and flow measured using coronary guidewire-based techniques. Conclusion: This novel methodology provides key insights into the physiological characteristics of epicardial and microvascular spasm during ACh provocation testing. Further clinical validation is required to explore the clinical utility of this methodology. </p>.

Indexed as

AcetylcholineCoronary VasospasmCoronary VesselsVascular ResistanceCoronary CirculationHumansHydrodynamicsMicrocirculationModels, CardiovascularVasodilator AgentsAcetylcholineVasodilator AgentsEpicardial spasmHydrodynamic methodMicrovascular spasmProvocative spasm testing

Identifiers

PMID40587946
PMCPMC12503449

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.