Evidence map›Paper›PMID 40587900›Full record

ArticleJournal of neurosurgery. Case lessons2025

Endoscopic endonasal surgery using indocyanine green fluorescence endoscope for Cushing's disease caused by mixed intrasellar gangliocytoma and adrenocorticotropin adenoma: illustrative case.

Yuefei Wang, Haixia Cheng, Wenqiang He, Qilin Zhang, Shun Yao, Zhengyuan Chen, Zengyi Ma, Xuefei Shou, Ming Shen, Yongfei Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurosurgery. Case lessons, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuefei WangDepartment of Neurosurgery, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, China.
Haixia ChengDepartment of Pathology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Wenqiang HeDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Qilin ZhangDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Shun YaoDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Zhengyuan ChenDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Zengyi MaDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Xuefei ShouDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Ming ShenDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Yongfei WangDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMixed gangliocytoma-adenoma (MGA) is an uncommon tumor found in the sellar region, characterized by both gangliocytic and pituitary adenomatous components. Preoperative differentiation of these mixed tumors from typical pituitary adenomas can be challenging, making thorough histological examination following resection essential for accurate diagnosis. However, the presence of the neural component in the gangliocytoma does not seem to affect its aggressiveness or recurrence risk after surgery. OBSERVATIONS: In the present study, the authors report a case of Cushing's disease secondary to a mixed pituitary adrenocorticotropin adenoma coexisting with an intrasellar gangliocytoma. Innovative preoperative C-X-C chemokine receptor type 4 (CXCR4)-targeted positron emission tomography (PET)/MRI and an intraoperative indocyanine green (ICG) fluorescence endoscope were used to localize the pathology. Biochemical remission was achieved after gross-total resection. LESSONS: Gross-total resection of the tumor is a curative management strategy for MGAs. MGA should be suspected if the intraoperative frozen section shows gliosis with ganglion-like neurons but not adenomas. Preoperative CXCR4-targeted PET/MRI can help to localize the pathology causing Cushing's disease. An intraoperative ICG fluorescence endoscope can be used to differentiate the pathology from normal gland tissue. https://thejns.org/doi/10.3171/CASE25237.

Indexed as

Cushing’s diseaseendoscopic transsphenoidal surgerygangliocytomaindocyanine green fluorescence endoscopepituitary adenoma

Identifiers

PMID40587900
PMCPMC12210058

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.