SynthesisAmerican journal of respiratory cell and molecular biology2025
Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma.
Synthesis in American journal of respiratory cell and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Sex Differences in Asthma Pathogenesis.Immunological reviews · 2026Review
- "Scripts" Don't Lie: Sex and Age Shape Blood Immune Gene Expression in Asthma.American journal of respiratory cell and molecular biology · 2025Article
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Authors and funding
12 authors.
Funding
Abstract
Asthma prevalence and severity differs between male and female individuals across the lifespan. Prepubescent boys are more likely to experience asthma, but girls are disproportionately affected after puberty, with greater symptom burden and decreased type 2 inflammation. However, because the human male and female genomes are almost identical, it is especially difficult to identify differentially expressed genes by sex to account for differences in disease susceptibility and manifestations without large sample sizes. Although several genes and genetic polymorphisms lead to sex-specific effects in asthma risk, the effects of sex-biased gene expression on clinical features within patients with asthma remain understudied. In this study, we characterized gene expression differences between female and male individuals through meta-analysis of transcriptomes of blood samples from adult patients with and without asthma in a large gene expression database (
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