ArticleJCO oncology practice2026
Real-World Adherence Patterns of Comprehensive Genomic Profiling to Biomarker Recommended Therapies in Patients With Advanced Non-Small Cell Lung Cancer.
Article in JCO oncology practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Real-world effectiveness of pembrolizumab for first-line treatment of metastatic non-small-cell lung cancer: a decade of evidence and experience.Future oncology (London, England) · 2026Review
- The Waiting Game: How NGS and Guideline-Concordant-Care Timing Shape Survival in Advanced NSCLC.Cancers · 2026Article
- Two-year treatment-free sustained remission after chemo-immunotherapy in a 52-year-old male with recurrentTranslational lung cancer research · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe National Comprehensive Cancer Network (NCCN) guidelines recommend comprehensive genomic profiling (CGP) for identifying advanced non-small cell lung cancer (NSCLC) patients eligible for targeted treatment, with frequent updates to incorporate new variant-targeted therapies. CGP panels can identify multiple actionable biomarkers from a single sample to match patients to targeted therapies. We assessed the adherence rate of NCCN recommendations to variant-specific matched therapy, the impact of timing of guideline updates on adherence rates, and time from sequencing to new targeted therapy adoption.
methodsWe conducted a retrospective cohort study of stage IV NSCLC patients, with Tempus xT tissue-based sequencing. Adherence to NCCN-recommended therapy was defined as the proportion of patients who initiated guideline-directed targeted therapy when the presence of an actionable variant was identified.
resultsAmong the 1,407 evaluable patients, 233 patients had a NCCN-recommended targetable variant. The treatment adherence rate was 86.3% (N = 201) with median time from sequencing to targeted therapy initiation of 23 days. A subset of adherent patients (13.4%, n = 27) had targetable variants identified prior to guideline recommendation for testing, but received matched targeted therapy within a median of 96 days of new guidelines recommendations. The variant-specific adherence rate was correlated with the timing of guideline recommendation (
conclusionIn a large, real-world cohort of advanced NSCLC patients tested with CGP, the treatment adherence rate to matched NCCN-recommended targeted therapy was high. This study highlights the importance of CGP testing in identifying variants to provide timely matched targeted therapy in a rapidly evolving biomarker and therapeutic landscape.
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