ArticleProceedings of the National Academy of Sciences of the United States of America2025
Total synthesis and biological activity of "carbamorphine": O-to-CH
Sota Akiyama, Rohini S Ople, Alexander Kremsmair, Nokomis Ramos-Gonzalez, Thomas Nedungadan, Brandon J Kennedy, Kevin Appourchaux, Shainnel O Eans, Bowen A Tsai, Christina Kraml and 4 more
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Sota Akiyama *Department of Chemistry, University of California, Berkeley, CA 94720.
Rohini S Ople *Department of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO 63110.
Alexander KremsmairDepartment of Chemistry, University of California, Berkeley, CA 94720.
Nokomis Ramos-GonzalezDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO 63110.
Thomas NedungadanDepartment of Chemistry, University of California, Berkeley, CA 94720.
Kevin AppourchauxDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO 63110.
Shainnel O EansDepartment of Pharmacodynamics, University of Florida, Gainesville, FL 32610.
Christina KramlLotus Separations, Frick Chemistry Lab, Princeton University, Princeton, NJ 08544.
Xi-Ping HuangDepartment of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599.
Susruta MajumdarDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-2931-3823 Funding
Strategies and Methods for Complex Molecule Synthesis: Acquisition of a 400 MHz Nuclear Magnetic Resonance Spectrometer ConsoleR35GM130345 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Richmond Sarpong · 2019 to 2026
$5.4MTargeting the allosteric sodium site with novel probes for delta opioid receptorR01DA057790 · NIDA · WASHINGTON UNIVERSITY · PI Tao Che, VSEVOLOD KATRITCH · 2023 to 2026
$2.6MAcquisition of a Cryoprobe and Related Accessories for a 600 MHz NMR Spectrometer to Support Health Research Activities at the University of California, BerkeleyS10OD024998 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARTWIG, JOHN F · 2018 to 2018
$265kHHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM130345HHS | NIH | National Institute on Drug Abuse (NIDA) RO1DA057790NIDA NIH HHS R01 DA057790NIGMS NIH HHS R35 GM130345NIH HHS S10 OD024998
6 · The paper itselfAbstract
Morphine is a µ-opioid receptor (MOR) agonist and potent analgesic. However, it displays several side effects including respiratory depression and addiction. Here, we show that a single heavy atom replacement in the morphine core structure (O to CH
Indexed as
Analgesics, OpioidMorphineMorphine DerivativesReceptors, Opioid, muAnimalsHumansMaleMiceStereoisomerismAnalgesics, OpioidMorphineMorphine DerivativesReceptors, Opioid, muantinociceptionmorphineopioidssingle-atom changetotal synthesis
Identifiers
PMID40587788
PMCPMC12260398
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
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