Evidence map›Paper›PMID 40587787›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

FtsZ-mediated spatial-temporal control over septal cell wall synthesis.

Longhua Hu, Amilcar J Perez, Tanya Nesterova, Zhixin Lyu, Atsushi Yahashiri, David S Weiss, Jie Xiao, Jian Liu

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Longhua Hu *Department of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.ORCID 0000-0003-2507-7576
Amilcar J Perez *Center for Cell Dynamics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.
Tanya NesterovaDepartment of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.
Zhixin LyuCenter for Cell Dynamics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.ORCID 0000-0001-7668-614X
Atsushi YahashiriDepartment of Microbiology, The University of Iowa, Iowa City, IA 52242.
David S WeissDepartment of Microbiology, The University of Iowa, Iowa City, IA 52242.ORCID 0000-0003-2217-0070
Jie XiaoCenter for Cell Dynamics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.ORCID 0000-0003-1433-5437
Jian LiuDepartment of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.ORCID 0000-0003-2935-0349

Funding

Program of Molecular BiophysicsT32GM135131 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Karen G. Fleming · 2020 to 2026
$5.4M
Spatial Organization and Regulation of Bacterial Cellular ProcessesR35GM136436 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Jie Xiao · 2020 to 2026
$4.8M
Probing the structure, dynamics and function of the E. coli divisomeR01GM086447 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI XIAO, JIE · 2011 to 2019
$3.8M
Predictive multi-scale model of focal adhesion-based durotaxisR01GM148459 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Jian Liu · 2023 to 2026
$1.6M
Peptidoglycan binding protein specificity and bacterial cell divisionR01GM125656 · NIGMS · UNIVERSITY OF IOWA · PI WEISS, DAVID S · 2018 to 2021
$1.3M
Elucidating the spatiotemporal regulation of septal peptidoglycan synthases in E.coliF32GM150262 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI PEREZ, AMILCAR JOSUE · 2023 to 2024
$151k
HHS | National Institutes of Health (NIH) R01GM125656HHS | National Institutes of Health (NIH) R01GM148459HHS | National Institutes of Health (NIH) R35GM13643NIGMS NIH HHS F32 GM150262NIGMS NIH HHS R01 GM086447NIGMS NIH HHS R01 GM125656NIGMS NIH HHS R01 GM148459NIGMS NIH HHS R35 GM136436NIGMS NIH HHS T32 GM135131NSF | BIO | Division of Molecular and Cellular Biosciences (MCB) 2105837NSF | BIO | Division of Molecular and Cellular Biosciences (MCB) 2148534
6 · The paper itself

Abstract

FtsZ, the tubulin-like GTPase, is the central organizer of the bacterial divisome, a macromolecular complex that synthesizes new septal cell wall (made of septal peptidoglycan, sPG) to allow cell wall constriction and cytokinesis. In

Indexed as

Bacterial ProteinsCell WallCytoskeletal ProteinsEscherichia coliCell DivisionCytokinesisEscherichia coli ProteinsMembrane ProteinsPeptidoglycanBacterial ProteinsCytoskeletal ProteinsEscherichia coli ProteinsFtsN protein, E coliFtsZ protein, BacteriaMembrane ProteinsPeptidoglycanBrownian ratchetFtsZseptal cell wall synthesissingle-molecule microscopytheoretical modeling

Identifiers

PMID40587787
PMCPMC12260396

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.