Evidence map›Paper›PMID 40587784›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

SpbR controls lipoteichoic acid length by directly inhibiting signal peptidase SpsB in

Youngseon Park, Tyler A Sisley, Madeleine C Stone, Rebecca M Corrigan, Christopher R Vickery, Angelika Gründling, Suzanne Walker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Youngseon Park *Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-2591-2650
Tyler A Sisley *Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-7711-6234
Madeleine C Stone *Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-6886-6589
Rebecca M CorriganSection of Molecular Microbiology and Centre for Bacterial Resistance Biology, Department of Infectious Disease, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0002-6031-1148
Christopher R VickeryDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.
Angelika GründlingSection of Molecular Microbiology and Centre for Bacterial Resistance Biology, Department of Infectious Disease, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0002-6235-8687
Suzanne WalkerDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-0545-914X

Funding

Technical Mother Machine CoreP01AI083214 · NIAID · SCHEPENS EYE RESEARCH INSTITUTE · PI David C Hooper · 2009 to 2026
$39.4M
Project 3: Defining and defeating the mechanisms of outer membrane biogenesis in Gram-negative bacteriaU19AI158028 · NIAID · HARVARD MEDICAL SCHOOL · PI WALKER, SUZANNE · 2022 to 2025
$10.1M
Discovery and characterization of new bacterial cell wall targets and inhibitors to treat resistant infectionsR01AI148752 · NIAID · HARVARD MEDICAL SCHOOL · PI Daniel Kahne, Suzanne Walker · 2020 to 2026
$5.5M
NIAID NIH HHS P01 AI083214NIAID NIH HHS R01 AI148752NIAID NIH HHS U19 AI158028
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Bacterial ProteinsLipopolysaccharidesMembrane ProteinsSerine EndopeptidasesStaphylococcus aureusTeichoic AcidsCell WallGene Expression Regulation, BacterialPeptidoglycanBacterial ProteinsLipopolysaccharideslipoteichoic acidMembrane ProteinsPeptidoglycanSerine EndopeptidasesTeichoic Acidstype I signal peptidaseCAAX proteaselipoteichoic acidsignal peptidaseStaphylococcus aureustransposon sequencing

Identifiers

PMID40587784
PMCPMC12260438

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.