Evidence map›Paper›PMID 40587782›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

A transcriptomic, proteomic, and functional genetic atlas dissects neurofibromin function in the peripheral nervous system.

Harish N Vasudevan, Nadia Arang, Maria Sacconi Nunez, Patrick Kennedy, Emily Payne, Sarah Mohabeer, Julian Chien, Aaron Wright, Matthew J Sale, Nevan J Krogan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Harish N VasudevanDepartment of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143.
Nadia ArangDepartment of Cellular and Molecular Pharmacology, Quantitative Biosciences Institute, University of California, San Francisco, CA 94158.
Maria Sacconi NunezDepartment of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143.
Patrick KennedyDepartment of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143.
Emily PayneDepartment of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143.
Sarah MohabeerDepartment of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143.
Julian ChienDepartment of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143.
Aaron WrightDepartment of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143.
Matthew J SaleDepartment of Cellular and Molecular Pharmacology, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94158.
Nevan J KroganDepartment of Cellular and Molecular Pharmacology, Quantitative Biosciences Institute, University of California, San Francisco, CA 94158.ORCID 0000-0003-4902-337X
Antoine ForgetDepartment of Cellular and Molecular Pharmacology, Quantitative Biosciences Institute, University of California, San Francisco, CA 94158.
Frank McCormickDepartment of Cellular and Molecular Pharmacology, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94158.ORCID 0000-0002-6619-7120

Funding

New Ways of Targeting K-RasR35CA197709 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCCORMICK, FRANK PATRICK · 2016 to 2022
$6.7M
Children's Tumor Foundation (CTF) N/ADOD | MHS | Congressionally Directed Medical Research Programs (CDMRP) NF230085DOD | MHS | Congressionally Directed Medical Research Programs (CDMRP) W81XWH2010129JHU | Neurofibromatosis Therapeutic Acceleration Program (NTAP) N/ANCI NIH HHS R35 CA197709
6 · The paper itself

Abstract

The

Indexed as

Neurofibromin 1Peripheral Nervous SystemTranscriptomeAnimalsBenzimidazolesCell ProliferationHumansNeurofibromatosis 1ProteomicsAZD 6244BenzimidazolesNeurofibromin 1NF1 protein, humanneurofibrominperipheral nervous systemRas inhibitor

Identifiers

PMID40587782
PMCPMC12260521

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.