ArticleAnalytical chemistry2025
Cross-Signal Contribution as a Challenge in LC-MS/MS Bioanalysis.
Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Liquid chromatography-tandem mass spectrometry is one of the most sensitive and reliable techniques in the quantitative bioanalysis of small molecules, but it is not free of challenges and traps. This Tutorial focuses on the possible causes of cross-signal contribution, which is often neglected, with seven real-world case studies in which interferences of different origins were identified and related problems were solved. A flowchart is suggested that guides readers step-by-step to narrow down the plausible reasons for the unexpected peaks in their LC-MS/MS assays. The impact of cross-signal contribution on quantitative bioanalysis is also discussed, along with measures that can be undertaken when the phenomenon has been identified.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.