Stereoisomers of Chiral Methyl-Substituted Symmetric and Asymmetric Aryl Piperazinium Compounds Exhibit Distinct Selectivity for α9 and α7 Nicotinic Acetylcholine Receptors.
Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors.
Hina AndleebDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts 02115, United States.ORCID 0000-0003-1992-6201
Roger L PapkeDepartment of Pharmacology and Therapeutics, University of Florida, PO Box 100267 Gainesville, Florida 32610, United States.ORCID 0000-0002-4468-8658
Katrin RichterDepartment of General and Thoracic Surgery, Laboratory of Experimental Surgery, Justus-Liebig-University, German Center for Lung Research [DZL], Cardio-Pulmonary Institute [CPI],, Giessen 35385, Germany.
Veronika GrauDepartment of General and Thoracic Surgery, Laboratory of Experimental Surgery, Justus-Liebig-University, German Center for Lung Research [DZL], Cardio-Pulmonary Institute [CPI],, Giessen 35385, Germany.
Arik J HoneSchool of Biological Sciences, University of Utah, Salt Lake City, Utah 84112, United States.ORCID 0000-0002-9912-0955
Andrew KerrCenter for Biomolecular Science and Engineering, US Naval Research Laboratory, Washington D.C. 20375, United States.
J Michael McIntoshSchool of Biological Sciences, University of Utah, Salt Lake City, Utah 84112, United States.
Clare StokesDepartment of Pharmacology and Therapeutics, University of Florida, PO Box 100267 Gainesville, Florida 32610, United States.
Ganesh A ThakurDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts 02115, United States.ORCID 0000-0002-7468-8819
Funding
Targeting of Alpha7 nAChR for therapeutic effectsR01GM057481 · NIGMS · UNIVERSITY OF FLORIDA · PI PAPKE, ROGER L · 2000 to 2023
$7.6M
Development and Application of Nicotinic Acetylcholine Receptor Targeted Peptides for Biomedical ResearchR35GM136430 · NIGMS · UNIVERSITY OF UTAH · PI MCINTOSH, J MICHAEL · 2020 to 2024
$2.3M
Selective Probes for Alpha9* Nicotinic Acetylcholine ReceptorsR01NS140966 · NINDS · NORTHEASTERN UNIVERSITY · PI Ganesh A Thakur, PAUL WHITEAKER · 2025 to 2026
We have characterized families of phenylpiperazine (PP) compounds, studying their relative activity with α7 and α9* nicotinic acetylcholine receptors (nAChRs) and focusing on the effects of side groups on the phenyl ring (R
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Stereoisomers of Chiral Methyl-Substituted Symmetric and Asymmetric Aryl Piperazinium Compounds Exhibit Distinct Selectivity for α9 and α7 Nicotinic Acetylcholine Receptors. · full record | OpenQuestion