ArticlePloS one2025
Superior growth performance in carp fry achieved with chitosan-alginate encapsulated A-ghrelin versus free peptide: Evidence from physiological, molecular, and morphological analyses.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Effects of dietary chitosan-flaxseed oil nanoemulsion on growth, economic performance, immunity, intestinal health, and cold-stress resistance in Nile tilapia (Oreochromis niloticus).Veterinary research communications · 2026Article
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Authors and funding
7 authors.
Funding
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Abstract
This study investigates the potential of delivering ghrelin via chitosan-alginate (Cs-Al) nanocapsules to enhance growth performance, immune function, and stress biomarker parameters in common carp fry (Cyprinus carpio). Characterization of the nanoparticles revealed an average size of 130 nm for Cs-Al particles and 150 nm for A-ghrelin-loaded nanoparticles, with polydispersity indices (PDI) of 0.3 and 0.4, respectively. The zeta potential was measured at +20 mV for Cs-Al nanoparticles and +22 mV for ghrelin-loaded nanoparticles. Morphological analysis using FE-SEM and AFM revealed that the nanoparticles exhibit a predominantly spherical and uniform morphology, while FTIR analysis confirmed their successful synthesis and functionalization. The A-Ghrelin-Cs-Al NP group showed superior growth performance, with higher weight gain vs. control (P < 0.05) and thicker intestinal walls (P < 0.05). While all ghrelin treatments elevated IGF-1 expression (P < 0.05 vs. control), the Cs-Al NP delivery system reduced IgM levels (P < 0.05) and C3 (P < 0.05) compared to free A-Ghrelin, suggesting encapsulation may modulate immune responses. No significant differences in gill morphology were observed between groups (P > 0.05). These findings highlight the potential of ghrelin, particularly when delivered through alginate-chitosan nanocapsules, as a promising tool to promote growth and physiological health in juvenile fish. This approach offers a novel strategy to enhance aquaculture productivity and sustainability through nanotechnology-based delivery systems.
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