Evidence map›Paper›PMID 40587418›Full record

ArticlePlant physiology2025

A comprehensive model of tomato fruit ripening regulation by the transcription factors NOR-like1, NAC-NOR, and MADS-RIN.

Victor Aprilyanto, Xiaowei Wang, Rufang Wang, Stan Kronenberg, Feitse Bos, Cristian Peña-Ponton, Gerco C Angenent, Ruud A de Maagd

Abstract read
In one paragraph

Article in Plant physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Victor AprilyantoLaboratory of Molecular Biology, Wageningen University, Wageningen 6700HB, The Netherlands.ORCID 0000-0002-1494-4905
Xiaowei WangLaboratory of Molecular Biology, Wageningen University, Wageningen 6700HB, The Netherlands.ORCID 0000-0002-7479-8858
Rufang WangInstitute of Facility Agriculture, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China.ORCID 0000-0002-7285-0878
Stan KronenbergLaboratory of Molecular Biology, Wageningen University, Wageningen 6700HB, The Netherlands.ORCID 0009-0009-1108-2391
Feitse BosLaboratory of Molecular Biology, Wageningen University, Wageningen 6700HB, The Netherlands.ORCID 0009-0001-6795-1519
Cristian Peña-PontonLaboratory of Molecular Biology, Wageningen University, Wageningen 6700HB, The Netherlands.ORCID 0000-0003-0671-2124
Gerco C AngenentLaboratory of Molecular Biology, Wageningen University, Wageningen 6700HB, The Netherlands.ORCID 0000-0003-4051-1078
Ruud A de MaagdBioscience, Wageningen Plant Research, Wageningen 6700AA, The Netherlands.ORCID 0000-0001-7049-2029

Funding

China Scholarship Council 202106300012EU-RISE Evofruland 101007738Guangzhou Science and Technology Plan Project 2023B03J1271Indonesia Endowment Fund for Education 201911220215635International Science and Technology Collaboration of Guangdong Province 2023A0505050140Startup Fund of Guangdong Academy of Agricultural Sciences R2022YJ-YB3002
6 · The paper itself

Abstract

Tomato (Solanum lycopersicum) fruit ripening involves climacteric ethylene production, lycopene accumulation, texture softening, and flavor enhancement, a highly coordinated process accompanied by profound gene expression changes. To construct a comprehensive model of ripening regulation, we studied the effects on ripening phenotypes and underlying gene expression changes in combinations of knockout alleles of NON-RIPENING-like1 (NL1), NON-RIPENING (NAC-NOR, NOR), and RIPENING INHIBITOR (MADS-RIN). Thus, we demonstrated that the products of the putative paralogous transcription factor genes NL1 and NOR together orchestrate ripening initiation and progression through ethylene production. NL1, or the ethylene production that it induces, together with NOR, stimulates the gene expression of transcription factor MADS-RIN, which then becomes the major driver of all ripening processes studied here. NOR and, particularly, NL1 have relatively minor but discernable and clearly different quantitative contributions to the ripening progression after initiation. Thus, the comprehensive model establishes a hierarchy of gene expression events regulating the start and progression of fruit ripening.

Indexed as

FruitMADS Domain ProteinsModels, BiologicalPlant ProteinsSolanum lycopersicumTranscription FactorsEthylenesGene Expression Regulation, PlantPhenotypeethyleneEthylenesMADS Domain ProteinsPlant ProteinsTranscription Factors

Identifiers

PMID40587418
PMCPMC12305540

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.