ArticleJournal of visualized experiments : JoVE2025
Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings.
Article in Journal of visualized experiments : JoVE, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A review of the impact of circadian rhythm on motor function in stroke recovery patients.Frontiers in neurologyReview
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Authors and funding
8 authors.
Funding
Abstract
Physiological rhythms, including diurnal and circadian rhythms, play a critical role in health, with disturbances increasingly linked to cardiovascular disease and type 2 diabetes. These rhythms are closely tied to sleep-wake cycles, as changes in sleep timing or duration can alter diurnal and circadian rhythms, thereby disrupting physiological homeostasis. Additional factors, such as the timing of behaviors like food intake and/or physical activity, may modulate 24-h rhythms in manners that support health or promote chronic disease risk. Despite the growing recognition of the importance of biological rhythms, obtaining serial blood samples required to elucidate patterns in circulating factors remains a significant challenge in clinical research. Routine blood draw methods can be disruptive to sleep, potentially altering sleep and biological rhythms and subsequently influencing variables of interest. This underscores the need for minimally invasive approaches that allow for the assessment of 24-h biological processes without disturbing sleep or biological rhythms. To address these challenges, many clinical and research groups employ a technique known as a "through-the-wall" blood sampling method. This approach uses extended tubing connected to an indwelling catheter, threaded through a wall or partition to a location outside the participant's room. By enabling blood collection without having to enter the room, this method minimizes disruptions, thereby preserving the integrity of the 24-h profiles of circulating variables of interest and minimally disturbing sleep. Here, we provide a detailed description of the through-the-wall blood sampling method and demonstrate its feasibility and efficacy in collecting blood samples during scheduled sleep opportunities. Representative data from a clinical study are presented, and additional considerations, including the impact of a difficult blood draw on sleep architecture, are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.