ArticleAnalytical chemistry2025
Multiple Exposures of Plasma to Nanoparticles: A Novel Tool to Personalize Biomolecular Coronas and Fractionate Fluids.
Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- High-Sensitivity Magnetic Levitation Reveals Intrinsic Protein Corona Heterogeneity on Identical Nanoparticles.bioRxiv : the preprint server for biology · 2026Article
- Navigating theNanoscale advances · 2026Review
- Mass Spectrometry Proteomics of the Nanoparticle Corona Is Highly Dependent on Sample Preparation Protocol.Proteomics · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanoparticles (NPs) have emerged as a valuable tool for biomarker discovery due to their ability to interact with biological fluids and form biomolecular coronas. In this study, we introduce a multiple exposure method that uses NPs to fractionate biological fluids and obtain personalized coronas. By repeatedly exposing plasma to silica NPs, we observed a progressive change of the biomolecule profile in both the pellet and supernatant. The varying protein and glycan composition of the corona was characterized using techniques such as SDS-PAGE, mass spectrometry, and UHPLC. Notably, the corona's composition evolved with each exposure cycle, reflecting the selective binding of proteins and glycosylated molecules from a corona of high-affinity biomolecules to a more diverse corona with very distinct structures. By tracing the sequential modification of protein and glycan composition, we believe that the method can be useful to trace specific biomarker profiles, offering a noninvasive alternative to conventional diagnostic processes with the potential to become a useful tool for disease monitoring and advanced biomedical applications.
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Registered trials
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