ReviewMolecular diagnosis & therapy2025
Fatty Acid Desaturase: The Yin or Yang of Disease Pathology.
Review in Molecular diagnosis & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Quantum molecular resonance and secretome synergistically unlocks a protective ceRNA axis in the human retinal pigment epithelium.Molecular therapy. Nucleic acids · 2026Article
- Targeting ferroptosis as a therapeutic strategy for hepatotoxicity.Toxicology reports · 2025Review
- Protective impact of circulating ω-3 PUFAs on sepsis susceptibility throughFrontiers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatty acid desaturases are key enzymes in lipid metabolism, crucial for converting saturated fatty acids into monounsaturated fatty acids. This review examines the roles of stearoyl-CoA desaturase, fatty acid desaturase 1, fatty acid desaturase 2 and fatty acid desaturase 3 in health and disease, highlighting their impact on cellular functions such as membrane fluidity, signalling and energy homeostasis. Dysregulation of desaturase activity can have significant implications for human health, contributing to the development of various pathological conditions, including cardiovascular disease, metabolic disorders and cancer. Fatty acid desaturase 1 and fatty acid desaturase 2 overexpression in cancer correlates with tumour growth and chemoresistance, marking them as potential therapeutic targets. The development of inhibitors targeting stearoyl-CoA desaturase and fatty acid desaturase 1 offers promising therapeutic avenues for metabolic diseases and cancer. This review underscores the critical roles of desaturases in various diseases. It emphasises the need for ongoing research to develop effective diagnostic, prognostic and therapeutic strategies, ultimately improving patient outcomes in altered fatty acid metabolism conditions.
Indexed as
Identifiers
40587082What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.