Trial reportSleep & breathing = Schlaf & Atmung2025
Supine position-related obstructive sleep apnea in children: insights from the Childhood Adenotonsillectomy Trial.
Trial report in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00560859 (A Randomized Controlled Study of Adenotonsillectomy for Children With Obstructive Sleep Apnea Syndrome), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Study of Adenotonsillectomy for Children With Obstructive Sleep Apnea Syndrome
Who cites it
1 citing paper in PubMed.
- Prevalence and Risk Factors of Positional Obstructive Sleep Apnea in Chinese Children: A Retrospective Study.Nature and science of sleep · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to examine the effectiveness of adenotonsillectomy (AT) among pediatric obstructive sleep apnea (OSA) patients with and without supine position-related OSA (POSA) and explore the stability of this subtype over time.
methodsData from the Childhood Adenotonsillectomy Trial (CHAT) were analyzed. Children with OSA were randomized to early AT (EAT) or watchful waiting with supportive care (WWSC). Polysomnographic and health outcomes were assessed at baseline and 7 months. POSA was defined as a supine obstructive apnea-hypopnea index (OAHI) ≥ 2× non-supine OAHI, with ≥ 30 min spent in each position.
resultsAmong 354 patients (mean age: 6.97 ± 1.39 years; male: 48.1%), 47.2% had POSA at baseline. Compared to non-POSA, children with POSA exhibited lower baseline OAHI [3.77 (2.48, 7.71) vs. 5.42 (3.03, 9.47) events/h, p = 0.006], longer rapid eye movement (REM) sleep in the supine position (p = 0.05), shorter REM sleep in non-supine position (p = 0.005), and fewer allergic conditions (37.7% vs. 48.4%, p = 0.05). Generalized linear models showed AHI reduction was associated with randomization grouping (p < 0.001) but not POSA status (p = 0.10). Our restricted cubic splines further supported this finding. Notably, in the WWSC group, POSA classification changed for half of the patients over 7 months, with changes in non-supine OAHI as a significant indicator.
conclusionAT is effective in managing childhood OSA regardless of POSA status. The observed dynamic nature of POSA warrants future research into its pathophysiology and natural history. CLINICAL
trial registrationChildhood Adenotonsillectomy Study for Children with OSAS (CHAT), Clinical Trial Identifier NCT00560859.
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