Evidence map›Paper›PMID 40587017›Full record

Trial reportUrolithiasis2025

Does suction in Mini PCNL mitigate rise in intrarenal pressure? A prospective randomised study.

Madhu Sudan Agrawal, Naveen Kumar, Dilip Mishra, Anurag Yadav, Laxmi Kant Sharma, Gaurav Sharma, Sachin Patel, Diptiranjan Bai

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Urolithiasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Madhu Sudan AgrawalInstitute of Urology and Renal Sciences, Pushpanjali Hospital and Research Centre, Agra, 282002, Uttar Pradesh, India. dr.madhu.agra@gmail.com.
Naveen KumarDepartment of Urology, Pushpanjali Hospital and Research Centre, Agra, 282002, Uttar Pradesh, India.
Dilip MishraDepartment of Urology, Pushpanjali Hospital and Research Centre, Agra, 282002, Uttar Pradesh, India.
Anurag YadavDepartment of Urology, Pushpanjali Hospital and Research Centre, Agra, 282002, Uttar Pradesh, India.
Laxmi Kant SharmaDepartment of Urology, Pushpanjali Hospital and Research Centre, Agra, 282002, Uttar Pradesh, India.
Gaurav SharmaDepartment of Urology, Pushpanjali Hospital and Research Centre, Agra, 282002, Uttar Pradesh, India.
Sachin PatelDepartment of Urology, Pushpanjali Hospital and Research Centre, Agra, 282002, Uttar Pradesh, India.
Diptiranjan BaiDepartment of Urology, Pushpanjali Hospital and Research Centre, Agra, 282002, Uttar Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rise in intra-renal pressure during Mini PCNL (percutaneous nephrolithotripsy) potentially leads to pyelovenous backflow and infectious complications. This prospective randomized study compares intra-renal pressure (IRP) in patients undergoing Mini PCNL (mPCNL) procedure with and without suction for renal stones. Suction mPCNL is expected to lower IRP by continuously aspirating irrigation fluid and stone fragments, thereby enhancing procedural safety. A total of 100 patients with kidney stones measuring 1-4 cm were randomized into two groups: Mini PCNL with suction (n = 50) and Mini PCNL without suction (n = 50). IRP was measured using a pressure transducer connected to a ureteral catheter. Key outcome measures included intra-renal pressure, stone-free rate, operative time, and complication rates. The suction mPCNL group demonstrated a significantly lower IRP (16.92 ± 2.93 mmHg) compared to the non-suction group (19.48 ± 4.77 mmHg, p = 0.002). The suction group also experienced shorter mean operative times (35.98 ± 14.10 min vs. 47.12 ± 15.36 min, p = 0.001) and lithotripsy times (19.50 ± 11.70 min vs. 26.24 ± 10.49 min, p = 0.003). The stone-free rate was higher in the suction group though this difference was not statistically significant. Likewise, the complication rates, including postoperative infection rates (fever and urosepsis) showed a downward trend in the suction group, however the difference was not statistically significant (p > 0.05). Suction mPCNL effectively reduces IRP, shortens operative time, maintains a comparable stone-free rate, making it a safer and more efficient alternative to traditional mPCNL. This study highlights the potential advantages of integrating suction mechanisms to control IRP and improve patient outcomes in PCNL procedures.

Indexed as

KidneyKidney CalculiNephrolithotomy, PercutaneousAdultAgedFemaleHumansMaleMiddle AgedOperative TimePostoperative ComplicationsPressureProspective StudiesSuctionTreatment OutcomeIntra-renal pressureKidney stonesMini PCNLPercutaneous nephrolithotomyPostoperative outcomesRandomized controlled trialStone-free rateSuction Mini PCNL

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.