ArticleEsophagus : official journal of the Japan Esophageal Society2025
Porphyromonas gingivalis levels correlate with TLR4 expression status and prognosis after esophagectomy for advanced thoracic esophageal squamous cell carcinoma.
Article in Esophagus : official journal of the Japan Esophageal Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Oral Environment of Esophageal Cancer Patients, the Incidence of Complications, and Long-Term Prognoses.Current oncology (Toronto, Ont.) · 2026Review
- Early esophageal squamous neoplasia and the microbiome: evidence, mechanisms, and early-detection potential.Frontiers in microbiology · 2026Review
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13 authors.
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Abstract
backgroundPoor oral health is an independent risk factor for upper-aerodigestive tract cancers, including esophageal squamous cell carcinoma (ESCC). Porphyromonas gingivalis (P. gingivalis), the most studied periodontal pathogen, is a Gram-negative bacterium with walls composed of lipopolysaccharide (LPS). TLR4 recognizes LPS, and we previously reported that ESCC patients exhibiting high TLR4 expression also show significantly poorer survival than patients expressing lower levels of TLR4. We therefore hypothesized that P. gingivalis affects disease progression and prognosis in patients with ESCC. PATIENTS AND
methodsWe used an ESCC tissue microarray to assess the P. gingivalis status of ESCC patients and to determine whether P. gingivalis levels correlate with prognosis after curative esophagectomy. We also tested whether the combined P. gingivalis and TLR4 statuses correlate with prognosis in these patients.
resultsClinical ESCC samples from 175 patients were tested for P. gingivalis. High P. gingivalis levels (3 + and 2 +) correlated with significantly poorer 5-year overall survival (OS) and disease-specific survival (DSS) after esophagectomy than lower P. gingivalis levels (1 + and 0). Univariate and multivariate analyses showed that the P. gingivalis status is an independent prognostic factor affecting 5-year OS and DSS. Moreover, the combined P. gingivalis and TLR4 statuses are also an independent prognostic factor affecting 5-year OS and DSS.
conclusionP. gingivalis levels correlates with TLR4 expression and predicts a poorer prognosis in ESCC patients after esophagectomy. Preventing P. gingivalis infection may be an effective strategy for improving the long-term outcomes of patients with ESCC.
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