Evidence map›Paper›PMID 40586949›Full record

ArticleMetabolic brain disease2025

Neuroprotective efficacy of Talinum triangulare in Cadmium-induced neurotoxicity: involvement of antioxidant defense, anti-inflammatory, dopaminergic, and cholinergic systems.

Johnson O Oladele, Ebenezer I O Ajayi, Isaac O Babatunde, Olaide O Awosanya, Oluwaseun T Oladele, Oluwafemi S Atolagbe, Omowumi O Adewale, Oyedotun M Oyeleke

Abstract read
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Article in Metabolic brain disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Johnson O OladeleDepartment of Chemical Sciences, Faculty of Science, Kings University, Ode-Omu, Osun State, Nigeria. Oladelejohn2007@gmail.com.ORCID 0000-0002-5434-1359
Ebenezer I O AjayiDepartment of Biochemistry, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeria.ORCID 0000-0001-6348-5840
Isaac O BabatundeDepartment of Biochemistry, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeria.ORCID 0000-0001-8524-6330
Olaide O AwosanyaPhytochemistry and Phytomedicine Research Unit, Royal Scientific Research Institute, Osogbo, Osun State, Nigeria.ORCID 0000-0002-0073-4042
Oluwaseun T OladeleDepartment of Biochemistry, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeria.ORCID 0000-0002-7599-3532
Oluwafemi S AtolagbeForestry Research Institute of Nigeria, Ibadan, Oyo State, Nigeria.ORCID 0000-0002-5083-501X
Omowumi O AdewaleDepartment of Biochemistry, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeria.ORCID 0000-0003-0387-585X
Oyedotun M OyelekeDepartment of Chemical Sciences, Faculty of Science, Kings University, Ode-Omu, Osun State, Nigeria.ORCID 0000-0002-9855-5295

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of neurotoxicity has been rising recently due to increase exposure to toxic compounds such as Cadmium (Cd). Aqueous leaf extract of Talinum triangulare (AETT) is used in traditional medicine in the treatment of various kinds of diseases. This study sought to examine neuroprotective potential of AETT on cadmium-induced neurotoxicity in rats. Neurotoxicity was induced in rats via oral administration of 5 mg/kg body weight CdCl

Indexed as

Anti-Inflammatory AgentsAntioxidantsCadmiumNeuroprotective AgentsNeurotoxicity SyndromesPlant ExtractsAnimalsBrainDopamineLipid PeroxidationMaleOxidative StressRatsRats, WistarAnti-Inflammatory AgentsAntioxidantsCadmiumDopamineNeuroprotective AgentsPlant ExtractsBehavioural incompetenceCadmiumMedicinal plantsNeurotoxicityTalinum triangulare

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.