Evidence map›Paper›PMID 40586940›Full record

Trial reportJournal of anesthesia2025

Comparing the effect of three levels of end-expiratory pressure during facemask ventilation on gastric insufflation in patients with obesity: a randomized controlled trial.

Maha Mostafa, Ahmed Hasanin, Mohamed M Zakaria, Hamza Kandel, Walid Hamimy, Ayman Abougabal, Mamdouh M Elshal

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of anesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05979129 (Comparing the Incidence of Gastric Insufflation During Facemask Ventilation at Different Levels of End-expiratory Pressure During Induction of Anesthesia in Obese Patients), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05979129 nacompletednot on this map

Comparing the Incidence of Gastric Insufflation During Facemask Ventilation at Different Levels of End-expiratory Pressure During Induction of Anesthesia in Obese Patients: a Randomized Controlled Study

TypeinterventionalSponsorKasr El Aini HospitalRan2023 to 2024Enrolled162ConditionsGastric Insufflation, Face-mask Ventilation, Obese, Positive End Expiratory PressureArmszero PEEP, low PEEP, high PEEP
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maha MostafaDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Ahmed HasaninDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt. ahmedmohamedhasanin@gmail.com.ORCID http://orcid.org/0000-0001-9947-5863
Mohamed M ZakariaDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Hamza KandelDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Walid HamimyDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Ayman AbougabalDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Mamdouh M ElshalDepartment of Anesthesia and Critical Care Medicine, National Cancer Institute, Cairo University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe compared the effect of three levels of end-expiratory pressure on the incidence of gastric insufflation during face-mask ventilation in patients with obesity.

methodsThis randomized controlled trial included adult obese patients undergoing elective non-cardiac surgery under general anesthesia with neuromuscular blockade. Patients were randomized to receive either zero-end-expiratory pressure (ZEEP group), 4-cmH

resultsWe analyzed data from 160 patients. The antral CSA increased after intubation in all groups. The incidence of gastric insufflation was higher in the high-PEEP group (32/54[59%]) than that in the ZEEP group (6/52[12%]) and low-PEEP group (15/54[28%]). Delta CSA, antral CSA after intubation, and incidence of gastric insufflation were not significantly different between the ZEEP and low-PEEP groups. Ventilatory variables were comparable between the groups.

conclusionIn obese paralyzed patients, gastric insufflation can occur during face-mask ventilation whatever the level of end-expiratory pressure; however, the use of ZEEP or 4-cmH CLINICAL

trial registrationClinical trial registration at clinicaltrials.gov NCT05979129. https://classic. CLINICALTRIALS: gov/ct2/show/NCT05979129.

Indexed as

InsufflationObesityPositive-Pressure RespirationAdultAnesthesia, GeneralFemaleHumansLaryngeal MasksMaleMiddle AgedPyloric AntrumStomachTidal VolumeFacemask ventilationGastric insufflationGastric ultrasoundObesePEEP

Identifiers

PMID40586940
PMCPMC12647190

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.