Evidence map›Paper›PMID 40586826›Full record

SynthesisBiochemical genetics2026

Association Between Seven Selected Genetic Polymorphisms in DNA Repair-Related Genes and Breast Cancer Risk: Evidence from a Comprehensive Meta-analysis Including 96 Studies.

Jiangyi Ruan, Hang Zhou, Zhengyu E, Yuping Chu, Shujing Zhang, Jiaxi Liao, Weiguang Zhou, Bifeng Chen

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Biochemical genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The authors respond to feedback onFrontiers in oncology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiangyi Ruan *Department of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, China.
Hang Zhou *Department of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, China.
Zhengyu EInstitute of WUT-AMU, Wuhan University of Technology, Wuhan, 430070, China.
Yuping ChuInstitute of WUT-AMU, Wuhan University of Technology, Wuhan, 430070, China.
Shujing ZhangDepartment of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, China.
Jiaxi LiaoDepartment of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, China.
Weiguang ZhouDepartment of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, China.
Bifeng ChenDepartment of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, China. cbifeng@whut.edu.cn.

Funding

Fundamental Research Funds for the Central Universities WUT: 104972024KFYjc0078horizontal project WUT: 202401hx0157
6 · The paper itself

Abstract

Impaired DNA repair is a major driver for carcinogenesis and could promote aggressive cancer biology. Mammalian cells have evolved highly conserved DNA repair machinery to process DNA damage and maintain genomic integrity. Until now, multiple genetic polymorphisms in DNA repair-related genes have been extensively examined for their contribution to breast cancer (BC) risk, including BRCA1 gene rs799917, RAD51 gene rs1801321 and rs1801320, XRCC3 gene rs861539, XPC gene rs2228001, ERCC1 gene rs3212986, and XRCC1 gene rs25487. However, these studies have yielded conflicting results. To resolve the discrepancies and provide a more precise estimation of the association between these genetic polymorphisms and BC risk, a comprehensive meta-analysis including 96 studies was carried out. The statistical results indicated that rs1801320 in the Caucasian population, rs3212986 in the total population, and rs25487 in the Asian population were significantly associated with BC risk after Bonferroni correction. Collectively, our findings suggested that RAD51 gene rs1801320, ERCC1 gene rs3212986, and XRCC1 gene rs25487 may serve as the susceptible loci in BC pathogenesis, which are warranted to be confirmed and reinforced in future studies.

Indexed as

Breast NeoplasmsDNA RepairGenetic Predisposition to DiseasePolymorphism, Single NucleotideDNA-Binding ProteinsEndonucleasesFemaleHumansRad51 RecombinaseX-ray Repair Cross Complementing Protein 1DNA-Binding ProteinsEndonucleasesERCC1 protein, humanRad51 RecombinaseX-ray Repair Cross Complementing Protein 1X-ray repair cross complementing protein 3XRCC1 protein, humanBreast cancerDNA repair-related genesGenetic polymorphismsMeta-analysisSusceptibility

Identifiers

PMID40586826

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.