Observational studyIntensive care medicine2025
Short- and long-term outcomes and 15-year time trends of kidney replacement therapy in critically ill patients with obesity: an observational cohort.
Observational study in Intensive care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sodium bicarbonate therapy in severe metabolic acidemia: an individual patient data meta-analysis of the BICAR-ICU and BICAR-ICU2 trials.Critical care (London, England) · 2026Pooled it
- Noninvasive ventilation in postoperative critically ill patients with morbid obesity: secondary analysis of the EXTUBOBESE multicentre randomised clinical trial.British journal of anaesthesia · 2025Trial
- Acute kidney injury among intensive care unit patients in Denmark: temporal changes in mortality and kidney outcomes from 2010 to 2024.Critical care (London, England) · 2026Article
- Is postoperative ARDS different from medical ARDS?Critical care (London, England) · 2026Article
- Association between obesity and kidney outcomes in critically ill patients with acute kidney injury receiving continuous renal replacement therapy: a secondary analysis of the multicenter CRRTnet study.Critical care (London, England) · 2026Observational
- Morphological subphenotypes of acute pancreatitis-related acute respiratory distress syndrome.Critical care (London, England) · 2026Article
- Norepinephrine use at extubation in critically ill patients with obesity: a cohort study with multicenter validation.Intensive care medicine · 2025Observational
- Update on acute kidney injury: some progresses and a long way to go.Intensive care medicine · 2025Article
- Physiological comparison of noninvasive ventilation and CPAP on inspiratory efforts after extubation in critically ill patients with morbid obesity: a post-hoc analysis.Annals of intensive care · 2025Article
- Factors associated with women authorship over 25 years in high-impact critical care randomized controlled trials: the pipeline is still leaking.Critical care (London, England) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeObesity is a public health challenge and a risk factor for chronic and acute kidney injury (AKI). The impact of kidney replacement therapy (KRT) on mortality in this specific population remains unclear. The objectives of this study were to evaluate the association between KRT and short- and long-term outcomes in patients with obesity, and to analyze trends over time in mortality as well as AKI and KRT incidence.
methodsA retrospective analysis was conducted on all consecutive patients with obesity (body mass index ≥ 30 kg/m
resultsAmong 2,192 patients with obesity included in the study, 295 (13.5%) required KRT. The 90-day mortality was significantly higher in the KRT group compared to the non-KRT group (49.8% (95% CI [44.1-55.5] vs. 18.9% (95% CI [17.2-20.7]), p < 0.0001). Multivariate analysis confirmed that KRT was independently associated with increased mortality. Over the 15-year period, AKI incidence decreased (p < 0.001).
conclusionAmong critically ill obese patients, KRT was independently associated with increased 90-day mortality. These results highlight the need for prospective studies to better define optimal management strategies in this high-risk population.
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Registered trials
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