Evidence map›Paper›PMID 40586702›Full record

ArticleeLife2025

Evolution of lateralized gustation in nematodes.

Marisa Mackie, Vivian Vy Le, Heather R Carstensen, Nicole R Kushnir, Dylan L Castro, Ivan M Dimov, Kathleen T Quach, Steven J Cook, Oliver Hobert, Sreekanth H Chalasani and 1 more

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Evolution of sensory systems underlies the emergence of predatory feeding behaviors in nematodes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Marisa MackieDepartment of Biology, California State University, Northridge, Northridge, United States.ORCID https://orcid.org/0009-0001-5549-4453
Vivian Vy LeDepartment of Biology, California State University, Northridge, Northridge, United States.
Heather R CarstensenDepartment of Biology, California State University, Northridge, Northridge, United States.ORCID https://orcid.org/0000-0002-2679-3286
Nicole R KushnirDepartment of Biology, California State University, Northridge, Northridge, United States.ORCID https://orcid.org/0009-0008-9040-3669
Dylan L CastroDepartment of Biology, California State University, Northridge, Northridge, United States.
Ivan M DimovDepartment of Biology, California State University, Northridge, Northridge, United States.
Kathleen T QuachMolecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, United States.
Steven J CookDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, United States.ORCID https://orcid.org/0000-0002-1345-7566
Oliver HobertDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, United States.ORCID https://orcid.org/0000-0002-7634-2854
Sreekanth H ChalasaniMolecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, United States.ORCID https://orcid.org/0000-0003-2522-8338
Ray L HongDepartment of Biology, California State University, Northridge, Northridge, United States.ORCID https://orcid.org/0000-0003-1870-8659

Funding

Dissecting neural mechanisms integrating multiple inputs in C.elegansR01MH096881 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI CHALASANI, SREEKANTH H. · 2013 to 2022
$4.8M
Mapping of chemosensory neuron function to uncover changes in neuronal fatesSC1GM140970 · NIGMS · CALIFORNIA STATE UNIVERSITY NORTHRIDGE · PI HONG, RAY L · 2021 to 2024
$1.4M
Dissecting neural mechanisms integrating multiple inputs in C. elegansR56MH096881 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI CHALASANI, SREEKANTH H., HART, MICHAEL P · 2023 to 2024
$1.2M
NIH HHS R56MH096881NIH HHS SC1GM140970NIMH NIH HHS R01 MH096881
6 · The paper itself

Abstract

Animals with small nervous systems have a limited number of sensory neurons that must encode information from a changing environment. This problem is particularly exacerbated in nematodes that populate a wide variety of distinct ecological niches but only have a few sensory neurons available to encode multiple modalities. How does sensory diversity prevail within this constraint in neuron number? To identify the genetic basis for patterning different nervous systems, we demonstrate that sensory neurons in

Indexed as

Biological EvolutionNematodaSensory Receptor CellsTasteAnimalsCaenorhabditis eleganscalcium imagingdevelopmental biologylateral asymmetryPristionchus pacificus

Identifiers

PMID40586702
PMCPMC12208668

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.