Evidence map›Paper›PMID 40586608›Full record

ArticlemBio2025

A spatial transcriptomic atlas of the host response to oropharyngeal candidiasis.

Sunna Nabeela, Hayden McSwiggin, Rubens Daniel Miserani Magalhaes, Eliciane Cevolani Mattos, Mohammad Mannan, John T Dillon, Ashley Barbarino, Eman G Youssef, Shakti Singh, Wei Yan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. TuningJournal of fungi (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sunna NabeelaThe Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA.
Hayden McSwigginThe Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA.
Rubens Daniel Miserani MagalhaesThe Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA.
Eliciane Cevolani MattosThe Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA.
Mohammad MannanThe Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA.
John T DillonDepartment of Biological Sciences, University of Toledo, Toledo, Ohio, USA.
Ashley BarbarinoThe Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA.
Eman G YoussefThe Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA.
Shakti SinghThe Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA.
Wei YanThe Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA.
Ashraf S IbrahimThe Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA.ORCID 0000-0003-3787-8530
Heather R ContiDepartment of Biological Sciences, University of Toledo, Toledo, Ohio, USA.
Priya UppuluriThe Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA.ORCID 0000-0002-5889-054X

Funding

Targeting the regulatory mechanism of hyphae to lateral yeast growth as a novel therapeutic approach against candidiasisR01AI141794 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI UPPULURI, PRIYA · 2019 to 2022
$1.5M
Targeting evolutionarily acquired insertion sequences in Candida species, for development of antifungal drugsR21AI169276 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI UPPULURI, PRIYA · 2023 to 2024
$458k
Delineating host response to central venous catheter associated Candida albicans biofilm infections, and development of novel therapeutics to combat drug resistant biofilmsR21AI178352 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI UPPULURI, PRIYA · 2024 to 2025
$452k
Role of multi-drug resistant Candida auris Hyr1 / Iff-like proteins in virulence and their potential as vaccine targetsK01AI180591 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI Shakti Singh · 2024 to 2026
$405k
National Institute of Allergy and Infectious Diseases 1R01AI141794, 1R21AI169276, 1R21AI178352NIAID NIH HHS K01 AI180591NIAID NIH HHS R01 AI141794NIAID NIH HHS R21 AI169276NIAID NIH HHS R21 AI178352
6 · The paper itself

Abstract

Oropharyngeal candidiasis (OPC) caused by the fungus

Indexed as

Candida albicansCandidiasis, OralHost-Pathogen InteractionsTranscriptomeAnimalsDisease Models, AnimalFemaleGene Expression ProfilingMacrophagesMiceMice, Inbred C57BLTongueCandida albicansM2 macrophagesOPCspatial transcriptomicsSPRR

Identifiers

PMID40586608
PMCPMC12345175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.