Evidence map›Paper›PMID 40586605›Full record

ArticleThe Kaohsiung journal of medical sciences2025

Hypoxia-Enhanced Wharton's Jelly Mesenchymal Stem Cell Therapy for Liver Fibrosis: A Comparative Study in a Rat Model.

Wei-Ting Kuo, Chen-Yuan Hsiao, Sheng-Hao Chiu, Shu-Cheng Chou, Ching-Shu Chiang, Jui-Yu Chen, Solomon Chih-Cheng Chen, Tien-Hua Chen, Jia-Fwu Shyu, Chi-Hung Lin and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Kaohsiung journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wei-Ting KuoInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.ORCID https://orcid.org/0009-0003-7709-8544
Chen-Yuan HsiaoDivision of Cardiovascular Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei, Taiwan.ORCID https://orcid.org/0000-0001-7334-526X
Sheng-Hao ChiuInstitute of Anatomy and Cell Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Shu-Cheng ChouInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Ching-Shu ChiangDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
Jui-Yu ChenDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
Solomon Chih-Cheng ChenDepartment of Pediatrics, Chiayi Christian Hospital, Chiayi, Taiwan.ORCID https://orcid.org/0000-0003-0031-6147
Tien-Hua ChenInstitute of Anatomy and Cell Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Jia-Fwu ShyuDepartment of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan.
Chi-Hung LinInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Pei-Jiun TsaiInstitute of Anatomy and Cell Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Funding

Ministry of Science and Technology (MOST), Taiwan 107-2314-B-010-056-MY3Ministry of Science and Technology (MOST), Taiwan 110-2314-B-A49A-501-MY3Ministry of Science and Technology (MOST), Taiwan 113-2314-B-A49-046Taipei Veterans General Hospital V110C-145Taipei Veterans General Hospital V110D55-001-MY1-1Taipei Veterans General Hospital V110D55-002-MY1-1Taipei Veterans General Hospital V110D55-003-MY1-1Taipei Veterans General Hospital V111C-167Taipei Veterans General Hospital V111D61-003-MY2-1Taipei Veterans General Hospital V111D61-003-MY2-2Taipei Veterans General Hospital V112C-124Taipei Veterans General Hospital V113C-171Taipei Veterans General Hospital V113D72-004-MY2-1Taipei Veterans General Hospital V113D72-004-MY2-2
6 · The paper itself

Abstract

Liver fibrosis is a progressive disease that can lead to cirrhosis and liver failure, with limited treatment options. Wharton's jelly-derived MSCs (WJ-MSCs) have immunomodulatory and antifibrotic potential. Hypoxia preconditioning enhances MSC survival and paracrine activity, but its effects in liver fibrosis remain unclear. This study compares hypoxia and normoxia WJ-MSCs in a CCl

Indexed as

HypoxiaLiver CirrhosisMesenchymal Stem CellsMesenchymal Stem Cell TransplantationWharton JellyAnimalsCarbon TetrachlorideCell HypoxiaDisease Models, AnimalLiverMalePositron-Emission TomographyRatsRats, Sprague-DawleyCarbon Tetrachloridefibrosis regenerationhypoxia preconditioningliver fibrosisstem cell therapyWharton's jelly mesenchymal stem cells (WJ‐MSCs)

Identifiers

PMID40586605
PMCPMC12412563

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.