Evidence map›Paper›PMID 40586582›Full record

ArticlemBio2025

Ribosome deficiency induces

Zhihui Lyu, Cierra Wilson, Kalyn Weiss, Spencer Lewis, Kurt Fredrick, William Margolin, Jiqiang Ling

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Deficiency in theMicroorganisms · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhihui Lyu *Department of Cell Biology and Molecular Genetics, The University of Maryland, College Park, Maryland, USA.
Cierra Wilson *Department of Cell Biology and Molecular Genetics, The University of Maryland, College Park, Maryland, USA.
Kalyn WeissDepartment of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center, Houston, Texas, USA.
Spencer LewisDepartment of Cell Biology and Molecular Genetics, The University of Maryland, College Park, Maryland, USA.
Kurt FredrickDepartment of Microbiology, The Ohio State University, Columbus, Ohio, USA.
William MargolinDepartment of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center, Houston, Texas, USA.ORCID 0000-0001-6557-7706
Jiqiang LingDepartment of Cell Biology and Molecular Genetics, The University of Maryland, College Park, Maryland, USA.ORCID 0000-0003-4466-8304

Funding

Molecular analysis of accurate ribosomal translocationR01GM072528 · NIGMS · OHIO STATE UNIVERSITY · PI Kurt L Fredrick · 2005 to 2026
$5.8M
Mechanisms and Regulation of Cell Division in BacteriaR35GM131705 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI WILLIAM MARGOLIN · 2019 to 2026
$3.8M
Regulation and Physiological Roles of Translational FidelityR35GM136213 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI LING, JIQIANG · 2020 to 2024
$2.0M
NIGMS NIH HHS R01 GM072528NIGMS NIH HHS R01GM072528NIGMS NIH HHS R35 GM131705NIGMS NIH HHS R35GM131705NIGMS NIH HHS R35 GM136213NIGMS NIH HHS R35GM136213
6 · The paper itself

Abstract

The ribosome is the central hub for protein synthesis and is heavily targeted by antibiotics. Ribosomal mutations, antibiotic treatment, and nutrient starvation can alter translational efficiency and lead to stressed cells. Ribosome deficiency plays a critical role in stress responses and disease progression; yet, how it affects bacteria-host interactions remains poorly understood. In this study, we show that a ribosome-deficient strain exhibits a surprising morphological change from rod shape to filamentous in IMPORTANCE: Bacteria growing inside host cells encounter various stresses and have evolved multiple adaptive mechanisms. One such mechanism is morphological changes, such as from rod-shaped cells to filaments.

Indexed as

MacrophagesRibosomesSalmonella typhimuriumAnimalsBacterial ProteinsGene Expression Regulation, BacterialHistidineMiceOperonProtein BiosynthesisBacterial ProteinsHistidinebacteria-host interactionscell divisionribotoxic stressstress adaptationtranslational defect

Identifiers

PMID40586582
PMCPMC12345169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.