Evidence map›Paper›PMID 40586574›Full record

ReviewmBio2025

An exciting future for microbial molecular biology and physiology.

Andrew A Bridges, Leah Guthrie, McKenzie Lehman, Elizabeth H Kellogg, Samantha Wellington Miranda, Andrew Pountain, Anthony L Shiver, Andrew Varble, Molecular Biology and Physiology Community of the Council on Microbial Sciences, Heidi B Kaplan and 2 more

Abstract readReview
In one paragraph

Review in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrew A BridgesBiological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-8132-751X
Leah GuthrieDepartment of Bioengineering, University of California, Berkeley, California, USA.ORCID 0000-0002-9144-0110
McKenzie LehmanDepartment of Pathology, Microbiology and Immunology, College of Medicine, University of Nebraska, Omaha, Nebraska, USA.ORCID 0000-0002-3335-5284
Elizabeth H KelloggDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-9664-3179
Samantha Wellington MirandaDepartment of Microbiology, University of Washington, Seattle, Washington, USA.ORCID 0000-0001-5072-2608
Andrew PountainDepartment of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID 0000-0001-9651-5145
Anthony L ShiverDepartment of Bioengineering, Stanford University, Stanford, California, USA.ORCID 0000-0001-7094-3715
Andrew VarbleDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.ORCID 0000-0002-4534-630X
Molecular Biology and Physiology Community of the Council on Microbial Sciences
Heidi B KaplanDepartment of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Elizabeth A ShankDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID 0000-0002-4804-1966
Gisela StorzDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.ORCID 0000-0001-6698-1241

Funding

A universal pipeline for functional characterization of the human microbiota at a massive scaleRM1GM135102 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BUIE, CULLEN RICHARD, DEUTSCHBAUER, ADAM M · 2020 to 2024
$7.6M
Investigating the molecules and mechanisms of bacterial cell-cell interactionsR35GM145261 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Elizabeth Anne Shank · 2022 to 2026
$2.5M
Small, Noncoding RNAs and Small ORFSZ01HD001608 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STORZ, GISELA · 1991 to 2008
$2.3M
Structural Basis of Programmable DNA-Insertion via Cryo-EM Studies of CRISPR-Associated TnsCR01GM144566 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Elizabeth Kellogg · 2022 to 2026
$2.0M
Harnessing Broad-Specificity Phage Recombinases for Universal Bacterial Editing platformsDP2AI184732 · NIAID · UNIVERSITY OF ROCHESTER · PI Andrew Varble · 2024 to 2026
$1.4M
Small ORFsZ01HD008855 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STORZ, GISELA · 2008 to 2008
$516k
This way out: Spatiotemporal regulation of Vibrio cholerae biofilm dispersalR00AI158939 · NIAID · CARNEGIE-MELLON UNIVERSITY · PI BRIDGES, ANDREW A. · 2023 to 2024
$498k
Treatment of Multidrug-Resistant Staphylococcus aureus Orthopaedic-Device Related Biofilm Infections with Local Delivery of Lytic BacteriophageR21AI176067 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI AMBROSE, CATHERINE G, KAPLAN, HEIDI B · 2023 to 2024
$422k
Developing a single cell resolution understanding of pathogenesis and antibiotic tolerance in Staphylococcus aureusK22AI177517 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI POUNTAIN, ANDREW WILLIAM · 2024 to 2025
$270k
Evolution of bacterial communication systemsK99GM145768 · NIGMS · UNIVERSITY OF WASHINGTON · PI MIRANDA, SAMANTHA WELLINGTON · 2022 to 2023
$225k
Charles E. Kaufman Foundation KA2023-136488Eunice Kennedy Shriver National Institute of Child Health and Human Development HD001608-34, HD008855-18Intramural NIH HHS Z01 HD001608Intramural NIH HHS Z01 HD008855NIAID NIH HHS DP2 AI184732NIAID NIH HHS K22 AI177517NIAID NIH HHS R00 AI158939NIAID NIH HHS R21 AI176067NIGMS NIH HHS K99 GM145768NIGMS NIH HHS R01 GM144566NIGMS NIH HHS R35 GM145261NIGMS NIH HHS RM1 GM135102NIH HHS DP2AI184732NIH HHS K22AI177517-01NIH HHS K99GM145768NIH HHS R00AI158939NIH HHS R01GM144566NIH HHS R21AI176067-01NIH HHS R35GM145261NIH HHS RM1GM135102
6 · The paper itself

Abstract

Continuous advances in technologies ranging from deep sequencing and genetic manipulation to mass spectrometry, single cell imaging, and structural biology have led to previously unimaginable advances in our understanding of microbial physiology and the molecular mechanisms underlying microbial responses in a multitude of environments. Simultaneously, these advances are revealing how much more there is to learn. At the 2024 virtual retreat of the Molecular Biology and Physiology (MBP) Community of the Council on Microbial Sciences (COMS) of the American Society for Microbiology (ASM), eight early-career investigators, along with retreat attendees, discussed some of these astounding advances, as well as the challenges and opportunities the developments raise. Motivated by these discussions, we review the state-of-the-art in molecular microbiology and provide an outlook on this field. Our hope is that the topics discussed here can serve as an inspiration for the development of future technologies, resources, and guidelines and for the training of the next generation of microbiologists.

Indexed as

BacteriaBacterial Physiological PhenomenaMicrobiological TechniquesMicrobiologyMolecular Biologygenome-scale mutagenesismacromolecular structuresmicrobial communitiesmulti-omic datanon-model microbessingle-cell microscopysingle-cell sequencing

Identifiers

PMID40586574
PMCPMC12345256

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.