Evidence map›Paper›PMID 40586567›Full record

ArticleMicrobiology spectrum2025

Sphingosylphosphorylcholine is a substrate for the

Pauline DiGianivittorio, Kristin Schutz, Lauren A Hinkel, Matthew J Wargo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Molecular Mechanisms Underlying the Pathogenicity ofMedicina (Kaunas, Lithuania) · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Pauline DiGianivittorioDepartment of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Kristin SchutzDepartment of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Lauren A HinkelDepartment of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Matthew J WargoDepartment of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.ORCID 0000-0001-5659-749X

Funding

Multidisciplinary Training in Lung BiologyT32HL076122 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI IRVIN, CHARLES G, POYNTER, MATTHEW E · 2004 to 2023
$6.1M
Vermont Immunology/Infectious Diseases Training GrantT32AI055402 · NIAID · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI GARY E WARD · 2005 to 2026
$2.7M
Regulation of the virulence factor PlcH in Pseudomonas aeruginosaR56AI173006 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI WARGO, MATTHEW J · 2023 to 2023
$379k
Cystic Fibrosis Foundation WARGO24G0NHLBI NIH HHS T32 HL076122NIAID NIH HHS R56 AI173006NIAID NIH HHS T32 AI055402
6 · The paper itself

Abstract

Sphingolipids are critical to eukaryotic cell membrane structure and function and play important roles in a variety of host processes that impact infection. Thus, it is not surprising that many pathogens can perturb host sphingolipid homeostasis, often to promote pathogenesis.

Indexed as

Bacterial ProteinsPhosphorylcholinePseudomonas aeruginosaSphingomyelin PhosphodiesteraseSphingosineType C PhospholipasesHumansPseudomonas InfectionsSphingolipidsSphingomyelinsVirulence FactorsBacterial ProteinsPhosphorylcholineSphingolipidsSphingomyelin PhosphodiesteraseSphingomyelinsSphingosinesphingosine phosphorylcholineType C PhospholipasesVirulence Factorslipidpathogenesissphingosinesphingosylphosphorylcholine

Identifiers

PMID40586567
PMCPMC12323605

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.