Evidence map›Paper›PMID 40586563›Full record

ArticlemBio2025

A small heat shock protein Fmp28 influences virulence by regulating Als3 expression via the cAMP-PKA signaling pathway in

Junjun Tan, Qiong Liu, Zhiping Liu, Yanli Cao, Xiaomin Yu, Qianjun Zhao, Niya Hu, Yanling Liu, Yuwei Wan, Yeming Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Junjun TanThe First Affiliated Hospital of Nanchang University and School of Basic Medical sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.ORCID 0009-0000-2356-3840
Qiong LiuMedical Experimental teaching center, School of Basic Medical sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.ORCID 0000-0002-8950-6133
Zhiping LiuSchool of Basic Medicine, Gannan Medical University, Ganzhou, Jiangxi, China.
Yanli CaoMedical Experimental teaching center, School of Basic Medical sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.
Xiaomin YuMedical Experimental teaching center, School of Basic Medical sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.
Qianjun ZhaoThe First Affiliated Hospital of Nanchang University and School of Basic Medical sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.
Niya HuThe First Affiliated Hospital of Nanchang University and School of Basic Medical sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.
Yanling LiuThe First Affiliated Hospital of Nanchang University and School of Basic Medical sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.
Yuwei WanThe First Affiliated Hospital of Nanchang University and School of Basic Medical sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.
Yeming ZhangThe First Affiliated Hospital of Nanchang University and School of Basic Medical sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.
Huizhen TianThe First Affiliated Hospital of Nanchang University and School of Basic Medical sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.
Lingbing ZengThe First Affiliated Hospital of Nanchang University and School of Basic Medical sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.ORCID 0000-0001-8947-9799
Xiaotian HuangThe First Affiliated Hospital of Nanchang University and School of Basic Medical sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.ORCID 0000-0003-1145-8386

Funding

National Natural Science Foundation of China 31760261National Natural Science Foundation of China 32060040National Natural Science Foundation of China 32460049Natural Science Foundation of Jiangxi Province 20202BAB206062, 20204BCJL23054Natural Science Foundation of Jiangxi Province 20202BAB216045
6 · The paper itself

Abstract

Small heat shock proteins are evolutionarily conserved molecular chaperones with diverse cellular roles. However, our understanding of their functions in pathogenic microorganisms remains limited. In this study, we identified and characterized Fmp28, a novel small heat shock protein that enhances virulence in

Indexed as

Candida albicansCyclic AMPCyclic AMP-Dependent Protein KinasesFungal ProteinsGene Expression Regulation, FungalHeat-Shock Proteins, SmallSignal TransductionAnimalsBiofilmsCandidiasisGene DeletionGene Expression ProfilingVirulenceALS3 protein, Candida albicansCyclic AMPCyclic AMP-Dependent Protein KinasesFungal ProteinsHeat-Shock Proteins, SmallAls3Candida albicansFmp28small heat shock proteinvirulence

Identifiers

PMID40586563
PMCPMC12345260

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.