Evidence map›Paper›PMID 40586556›Full record

ArticleMolecular pharmaceutics2025

Hydrophilic and Amphiphilic Macromolecules as Modulators of the Physical Stability and Bioavailability of Piribedil: A Study on Binary Mixtures and Micellar Systems.

Luiza Orszulak, Aldona Minecka, Roksana Bernat, Taoufik Lamrani, Karolina Jurkiewicz, Barbara Hachuła, Magdalena Tarnacka, Monika Geppert-Rybczyńska, Maciej Zubko, Marcela Staniszewska and 5 more

Abstract read
In one paragraph

Article in Molecular pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Luiza OrszulakInstitute of Chemistry, Faculty of Science and Technology, University of Silesia in Katowice, Szkolna 9, 40-006 Katowice, Poland.ORCID 0000-0002-7709-5867
Aldona MineckaDepartment of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jagiellonska 4, 41-200 Sosnowiec, Poland.ORCID 0000-0001-5603-032X
Roksana BernatInstitute of Materials Engineering, University of Silesia in Katowice, 75 Pulku Piechoty 1A, 41-500 Chorzow, Poland.
Taoufik LamraniInstitute of Physics, Faculty of Science and Technology, University of Silesia in Katowice, 75 Pulku Piechoty 1A, 41-500 Chorzow, Poland.
Karolina JurkiewiczInstitute of Physics, Faculty of Science and Technology, University of Silesia in Katowice, 75 Pulku Piechoty 1A, 41-500 Chorzow, Poland.ORCID 0000-0002-4289-7827
Barbara HachułaInstitute of Chemistry, Faculty of Science and Technology, University of Silesia in Katowice, Szkolna 9, 40-006 Katowice, Poland.
Magdalena TarnackaInstitute of Physics, Faculty of Science and Technology, University of Silesia in Katowice, 75 Pulku Piechoty 1A, 41-500 Chorzow, Poland.ORCID 0000-0002-9444-3114
Monika Geppert-RybczyńskaInstitute of Chemistry, Faculty of Science and Technology, University of Silesia in Katowice, Szkolna 9, 40-006 Katowice, Poland.ORCID 0000-0002-7112-9624
Maciej ZubkoInstitute of Materials Engineering, University of Silesia in Katowice, 75 Pulku Piechoty 1A, 41-500 Chorzow, Poland.
Marcela StaniszewskaPhysiolution Polska sp. z o.o., Skarbowcow 81/7, 53-025 Wroclaw, Poland.ORCID 0000-0002-6865-5471
Michał SmoleńskiPhysiolution Polska sp. z o.o., Skarbowcow 81/7, 53-025 Wroclaw, Poland.ORCID 0000-0002-6075-9866
Justyna DoboszPhysiolution Polska sp. z o.o., Skarbowcow 81/7, 53-025 Wroclaw, Poland.
Grzegorz GarbaczPhysiolution Polska sp. z o.o., Skarbowcow 81/7, 53-025 Wroclaw, Poland.
Kamil KamińskiInstitute of Physics, Faculty of Science and Technology, University of Silesia in Katowice, 75 Pulku Piechoty 1A, 41-500 Chorzow, Poland.ORCID 0000-0002-5871-0203
Ewa KamińskaDepartment of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jagiellonska 4, 41-200 Sosnowiec, Poland.ORCID 0000-0001-9725-8654

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study presents an innovative approach that utilizes polymers with different topologies and properties as potential matrices for the poorly water-soluble active pharmaceutical ingredient piribedil (PBD). We investigated amorphous solid dispersions (ASDs) as well as micellar systems composed of PBD and (

Indexed as

PiribedilBiological AvailabilityCalorimetry, Differential ScanningChemistry, PharmaceuticalCrystallizationDrug CompoundingDrug LiberationDrug StabilityHydrophobic and Hydrophilic InteractionsMicellesPolyethylene GlycolsPolymersPolyvinylsSolubilitySpectroscopy, Fourier Transform InfraredX-Ray DiffractionMicellesPiribedilPolyethylene GlycolsPolymerspolyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymerPolyvinylsamorphous solid dispersionsbioavailabilitydrug delivery systemmicellar systemspiribedilpolyvinylpyrrolidonesolubilitySoluplus copolymertopology of polymers

Identifiers

PMID40586556
PMCPMC12326366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.