Evidence map›Paper›PMID 40586551›Full record

ArticlemBio2025

A redundant isoprenoid biosynthetic pathway supports

Troy A Burtchett, Elizabeth N Ottosen, Tomotaka Jitsukawa, Momoko Kaneko, Miu Yasui, Jessica A Lysne, Paige J Kies, Jessica A Bailey, Sean M Thomas, Shingo Fujisaki and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Troy A BurtchettMicrobiology, Genetics, & Immunology, Biomedical & Physical Sciences Building, Michigan State University, East Lansing, Michigan, USA.
Elizabeth N OttosenMicrobiology, Genetics, & Immunology, Biomedical & Physical Sciences Building, Michigan State University, East Lansing, Michigan, USA.
Tomotaka JitsukawaDepartment of Biomolecular Science, Faculty of Science, Toho University, Funabashi, Chiba, Japan.
Momoko KanekoDepartment of Biomolecular Science, Faculty of Science, Toho University, Funabashi, Chiba, Japan.
Miu YasuiDepartment of Biomolecular Science, Faculty of Science, Toho University, Funabashi, Chiba, Japan.
Jessica A LysneMicrobiology, Genetics, & Immunology, Biomedical & Physical Sciences Building, Michigan State University, East Lansing, Michigan, USA.
Paige J KiesMicrobiology, Genetics, & Immunology, Biomedical & Physical Sciences Building, Michigan State University, East Lansing, Michigan, USA.
Jessica A BaileyMicrobiology, Genetics, & Immunology, Biomedical & Physical Sciences Building, Michigan State University, East Lansing, Michigan, USA.
Sean M ThomasMicrobiology, Genetics, & Immunology, Biomedical & Physical Sciences Building, Michigan State University, East Lansing, Michigan, USA.
Shingo FujisakiDepartment of Biomolecular Science, Faculty of Science, Toho University, Funabashi, Chiba, Japan.
Neal D HammerMicrobiology, Genetics, & Immunology, Biomedical & Physical Sciences Building, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0001-6148-7850

Funding

Elucidating strategies of Staphylococcus aureus nutrient sulfur acquisition during infectionR01AI139074 · NIAID · MICHIGAN STATE UNIVERSITY · PI HAMMER, NEAL D. · 2019 to 2024
$2.4M
Examining host-derived glutathione as a sulfur source for Staphylococcus aureus during infectionR21AI142517 · NIAID · MICHIGAN STATE UNIVERSITY · PI HAMMER, NEAL D. · 2019 to 2020
$426k
Isoprenoid synthesis and allocation in Staphylococcus aureusR21AI144504 · NIAID · MICHIGAN STATE UNIVERSITY · PI HAMMER, NEAL D. · 2019 to 2020
$426k
Japan Society for the Promotion of Science JP22K053391NIAID NIH HHS R01 AI139074NIAID NIH HHS R21 AI142517NIAID NIH HHS R21 AI144504NIH HHS R21AI144504
6 · The paper itself

Abstract

Isoprenoids are ubiquitous molecules that serve as fundamental building blocks for life. In bacteria, isoprenoids are precursors for carotenoid pigments, respiratory cofactors, and essential sugar carrier lipids, such as lipid II. Isoprenoid synthesis initiates via condensation of the five-carbon (C IMPORTANCE: Isoprenoid synthesis is an essential process that is presumed to be initiated by the prenyl diphosphate synthase (PDS), IspA. However, our understanding of this pathway is incomplete considering that

Indexed as

Biosynthetic PathwaysStaphylococcus aureusTerpenesAnimalsDisease Models, AnimalFemaleHemiterpenesMiceOrganophosphorus CompoundsPolyisoprenyl PhosphatesPolymorphism, Single NucleotideSesquiterpenesStaphylococcal InfectionsXanthophyllsfarnesyl pyrophosphateHemiterpenesisopentenyl pyrophosphateOrganophosphorus CompoundsPolyisoprenyl PhosphatesSesquiterpenesstaphyloxanthinTerpenesXanthophyllsbacterial respirationfarnesyl diphosphateheme aheme oheptaprenyl diphosphate synthaseisoprenoidmenaquinoneprenyl diphosphate synthaseStaphylococcus aureusterminal oxidase

Identifiers

PMID40586551
PMCPMC12345219

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.