Evidence map›Paper›PMID 40586414›Full record

ReviewAnnals of neurology2025

Toward Natural Limb Function: A New Era in Prosthetic Innovation.

Yucheng Tian, Dylan M Wallace, Paul S Cederna, Cynthia A Chestek, Stephen W P Kemp

Abstract readReview
In one paragraph

Review in Annals of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yucheng Tian *Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Dylan M Wallace *Department of Robotics, University of Michigan, Ann Arbor, Michigan, USA.
Paul S CedernaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Cynthia A ChestekDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Stephen W P KempDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-5608-3584

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The past decade has witnessed groundbreaking clinical implementation of neuroprosthetic limbs driven by signals from peripheral targets (eg, nerves and muscle) and the brain to restore limb function for individuals with limb loss or impairment. In this review, we highlight recent key clinical trials in peripheral neuroprosthetic interfaces directly with nerve, residual muscle, and reinnervated muscle. We then highlight the key advances in brain interfaces, including clinical trials using electroencephalography, electrocorticography, and intracortical electrodes to control neuroprosthetics. Finally, we explore the future of neuroprosthetic control where both peripheral and brain interfaces can be combined to improve neuroprosthetic performance. ANN NEUROL 2025;98:913-928.

Indexed as

Artificial LimbsBrain-Computer InterfacesExtremitiesElectroencephalographyHumans

Identifiers

PMID40586414
PMCPMC12577683

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.