Evidence map›Paper›PMID 40586362›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2025

Nonfouling Coatings from Synthetic Intrinsically Disordered Proteins.

Chuanbao Zheng, Yulia Shmidov, Anastasia K Varanko, Sonal Deshpande, Yunqi Yang, Daniel M Shapiro, Zhisen Zhang, Han Zuilhof, Ashutosh Chilkoti, Renko de Vries

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Nonfouling Coatings from Synthetic Intrinsically Disordered Proteins.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chuanbao ZhengPhysical Chemistry and Soft Matter, Wageningen University & Research, Wageningen, 6708WE, The Netherlands.ORCID 0000-0002-0866-9839
Yulia ShmidovDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.ORCID 0000-0003-4152-0670
Anastasia K VarankoDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.ORCID 0000-0003-2763-5842
Sonal DeshpandeDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.ORCID 0000-0003-3055-0065
Yunqi YangDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
Daniel M ShapiroDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
Zhisen ZhangResearch Institute for Biomimetics and Soft Matter, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Department of Physics, Xiamen University, Xiamen, 361005, China.ORCID 0000-0002-8638-0993
Han ZuilhofLaboratory of Organic Chemistry, Wageningen University & Research, Wageningen, 6708WE, The Netherlands.ORCID 0000-0001-5773-8506
Ashutosh ChilkotiDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.ORCID 0000-0002-1569-2228
Renko de VriesPhysical Chemistry and Soft Matter, Wageningen University & Research, Wageningen, 6708WE, The Netherlands.ORCID 0000-0001-8664-3135

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The antifouling performance of a previously developed triblock protein, B-M-E is optimized, that self-assembles on gold surfaces to form a nonfouling layer by modifying the sequence of its E block. In this protein, B is a gold-binding domain, M is a trimerization domain, and E is a synthetic intrinsically disordered protein (IDP) that confers nonfouling behavior. To identify optimal sequences for the nonfouling E block, a few candidate IDPs are screened that provide a proxy for nonfouling behavior, such as extending the half-life of their fusion partners in systemic circulation and sequences that promote soluble expression of their fusion partners in E coli. One IDP is identified with the sequence [(GAGAIP)

Indexed as

BiofoulingIntrinsically Disordered ProteinsEscherichia coliGoldSurface PropertiesGoldIntrinsically Disordered Proteinsantifoulinggold surfacehuman serumintrinsically disordered polypeptidessolid‐binding peptides

Identifiers

PMID40586362
PMCPMC12393014

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.