ArticleEnvironmental science & technology2025
Exposures to Contemporary and Emerging Chemicals among Children Aged 2 to 4 Years in the United States Environmental Influences on the Child Health Outcome (ECHO) Cohort.
Article in Environmental science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Prevalent detection of multiclass environmental chemicals in paired CSF and plasma samples and their potential associations with postpartum depressive symptoms in pregnant women.Environmental research · 2026Article
- Multiclass Assays for Measuring Environmental Chemical Mixture Exposure: Analytical Methodologies and Applications in Exposomics Research.Metabolites · 2025Review
- Prenatal exposure to environmental phenolic compounds and their association with childhood atopic dermatitis, asthma, and allergic rhinitis in the ECHO cohort.Environment international · 2025Article
- Expanding the chemical exposome using in-silico transformation analysis - an example using insecticides.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
Prenatal and early life exposure to environmental chemicals can increase the risk of multiple adverse child health outcomes. However, biomonitoring data for young children remain limited. This study leveraged the nationwide Environmental influences on Child Health Outcomes (ECHO) Cohort to assess chemical exposures in 201 children aged 2-4 years between 2010 and 2021. A total of 111 analytes across multiple chemical classes were simultaneously quantified in single spot urine specimens collected from each child and their mother during pregnancy, and concentrations were compared between child and prenatal maternal samples. Among the 111 analytes, 96 were detected in at least five children and 48 analytes in over 50% of children. Thirty-four were ubiquitously detected (>90%), nine of which have not been included in U.S. national biomonitoring: benzophenone-1, triethyl phosphate, and metabolites of six phthalates and one alternative plasticizer. Concentrations of bisphenol S, three pesticide biomarkers, and two phthalate biomarkers were higher in children than in mothers, while those of triclosan and monoethyl phthalate were higher in mothers. This study reveals frequent exposure to multiple chemicals in young U.S. children, often exceeding prenatal levels. Expanded biomonitoring of emerging chemicals of concern and studies of their health effects in this vulnerable population are warranted.
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Registered trials
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